Results 1 to 10 of about 11,695 (173)

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen-Induced Arthritis Rats Through Modulation of the SIRT1/HIF-1α/Glycolysis Pathway. [PDF]

Pharmacol Res Perspect
ABSTRACT Securidaca inappendiculata (SI) Hassk. is a traditional Chinese herbal medicine commonly used in Southern China for the treatment of rheumatoid arthritis (RA). However, its exact mechanism of action remains unclear. In this study, we evaluated the therapeutic effects of the SI‐derived compound 1,7‐dihydroxy‐3,4‐dimethoxyxanthone (XAN) in a ...
Zhou Y, Zhou Y, Xiang R, Liu X, Wang T, Chen X, Wang G.   +6 more
europepmc   +2 more sources

Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging. [PDF]

Sci Adv
Li B, Nie S, Wang M, An J, Qian Z, Meng X, Edgington-Mitchell LE, Zhang Z, Yang X, Ye K.   +9 more
europepmc   +1 more source

Immunometabolic Biomarkers in Colorectal Cancer: An Exploratory Diagnostic Evaluation of PBEF/NAMPT, Chemerin, and Osteopontin. [PDF]

Int J Mol Sci
Szczygielski O, Dąbrowska E, Safiejko K, Juchimiuk M, Orywal K, Zajkowska M.   +5 more
europepmc   +1 more source

Computational Identification of New Dual PAK4 and NAMPT Inhibitors. [PDF]

Int J Mol Sci
Wang Y, Minden A.
europepmc   +1 more source

Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles. [PDF]

Diabetes
Ferguson D, Gadson EI, Markan KR, Yoshino J, Palacios H, Lin M, Habibi M, Tiash S, Cui X, Kouranova E, Franczak E, Guo Q, Nguyen T, Kealing J, Pietka TA, Liss KHH, Thyfault JP, Patti GJ, Finck BN, Crewe C, Mukherjee S.   +20 more
europepmc   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders. [PDF]

CNS Neurosci Ther
Chen Y, Du X, Li F, Yuan S, Wang W, Zhu Z, Wang M, Gu C.   +7 more
europepmc   +1 more source

The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits. [PDF]

Front Sports Act Living
Anas, Sundus H, Khan SA, Ahmed SS, Muruganantham P, Madar IH.   +5 more
europepmc   +1 more source

Artificial Intelligence-Guided Prioritization and Experimental Evaluation of Synergistic Target Combinations for Breast Cancer Therapy. [PDF]

Pharmaceuticals (Basel)
Feng C, Feng Q, She S, Yang R, Li M, Gong L, Rui M.   +6 more
europepmc   +1 more source

NAMPT shows tissue-dependent immune-metabolic associations in osteoarthritic synovium and aging-related skeletal muscle. [PDF]

Front Med (Lausanne)
He Q, Qin W, Yu X, Jing L, Yan Q.
europepmc   +1 more source

Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study. [PDF]

Front Cardiovasc Med
Shi Y, Yi W, Feng X, Zhang Q, Bao S, Sun L, Yan S, Li N, Li X.   +8 more
europepmc   +1 more source