Results 41 to 50 of about 11,695 (173)

Serum nicotinamide phosphoribosyltransferase as a novel biomarker for non-traumatic osteonecrosis of the femoral head

Journal of Orthopaedic Surgery and Research, 2022
Objective The aim of this study was to investigate the potential role of serum nicotinamide phosphoribosyltransferase (NAMPT) in non-traumatic osteonecrosis of femoral head (NONFH).
Shiying Wang, Huixian Zhan, Liping Xu, Baoxiang Zhao   +3 more
doaj   +1 more source

Immunohistochemical Analysis of Nicotinamide Phosphoribosyltransferase Expression in Gastric and Esophageal Adenocarcinoma (AEG)

Gastrointestinal Disorders, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) represents a major component in cellular energy metabolism, which is also crucial for cancer cells that have elevated aerobic glycolysis; moreover, targeting the NAD salvage pathway by inhibition of NAMPT ...
Alexander Arnold, Moritz von Winterfeld, Erika Berg, Michael Hummel, Beate Rau, Felix Krenzien, Ulrike Stein, Christoph Treese   +7 more
doaj   +1 more source

NAMPT single-nucleotide polymorphism rs1319501 and visfatin/NAMPT affect nitric oxide formation, sFlt-1 and antihypertensive therapy response in preeclampsia

, 2021
AIM: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether ...
Luizon, Marcelo R, Tanus-Santos, Jose E., Palei, Ana C., Cavalli, Ricardo C., Pereira, Daniela A, Sandrim, Valeria C, Lacchini, Riccardo, Cavalli, Ricardo C, Belo, Vanessa A., Palei, Ana C, Pereira, Daniela A., Tanus-Santos, Jose E, Luizon, Marcelo R., Amaral, Lorena M., Amaral, Lorena M, Belo, Vanessa A, Sandrim, Valeria C. [UNESP]   +16 more
core   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity

Therapeutic Advances in Respiratory Disease, 2023
Background and objectives: eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity.
Heather Lynn, Xiaoguang Sun, Nancy G. Casanova, Christian Bime, Vivian Reyes Hernon, Clayton Lanham, Radu C. Oita, Nikolas Ramos, Belinda Sun, Dawn K. Coletta, Sara M. Camp, Jason H. Karnes, Nathan A. Ellis, Joe G.N. Garcia   +13 more
doaj   +1 more source

NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells

Stem Cell Research & Therapy, 2021
Background Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs).
Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima, Julia Skokowa   +7 more
doaj   +1 more source

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

Lipids in Health and Disease, 2017
Background Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose
Melanie Penke, Susanne Schuster, Theresa Gorski, Rolf Gebhardt, Wieland Kiess, Antje Garten   +5 more
doaj   +1 more source

Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo

Brain Sciences, 2022
This study aimed to investigate the potential therapeutic effects of nicotinamide phosphoribosyltransferase (NAMPT)-mediated adenine dinucleotide (NAD) biosynthesis in depression models in vivo. Namptflox/flox mice were used to evaluate the role of NAMPT
Jue Wang, Runxuan Sun, Linhan Xia, Xinying Zhu, Qi Zhang, Yilu Ye   +5 more
doaj   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Davis, Julian R. E., Talbot, Richard, Dupre, Sandrine M., Loudon, Andrew S I; id_orcid, Waddington, D., Downing, A., Burt, D.W., Davis, Julian R E, Loudon, A.S.I., Talbot, R., Mouzaki, D., Davis, J.R.E., Downing, Alison, Lincoln, Gerald A., Mouzaki, Daphne, Dupré, S.M., Burt, Dave W., Lincoln, G.A., Waddington, David, Loudon, Andrew S. I., Dupre, Sandrine, Malpaux, Benoit   +21 more
core   +1 more source

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Frontiers in Oncology, 2019
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which ...
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He   +7 more
doaj   +1 more source