Results 61 to 70 of about 11,695 (173)
Frontiers in Endocrinology, 2020 Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity,
Andy Tran +6 more
doaj +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Nampt inhibitors evaluated for potency on mutant NAMPT enzymes.
, 2014 a) Chemical structures of NAMPT inhibitors, compound 1 is GNE-618, compound 9 is GMX1778, compound 11 is APO866. b) Fold change in IC50 of NAMPT inhibitors on purified mutant NAMPT proteins compared to wild-type enzyme.
Jiansheng Wu (193208) +17 more
core +1 more source
Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery
Advanced Science, EarlyView.DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong +8 more
wiley +1 more source
Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
Frontiers in Oncology, 2020 Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an increased reliance on NAD+ production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the ...
Christine M. Heske
doaj +1 more source
A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells. [PDF]
PLoS ONE, 2014 We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown.
Reiko Sanokawa-Akakura +4 more
doaj +1 more source
Advanced Science, EarlyView.Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li +9 more
wiley +1 more source
Overall survival by NAMPT IHC score.
, 2019 Kaplan-Meier curves showing overall survival of patients with NAMPT+ (blue line) and NAMPT- (red line) PDA. Median OS: 20.4 months (NAMPT+) vs. 26.0 months (NAMPT-); P-value: 0.34.
Po Hien Ear (6444044) +8 more
core +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To investigate the mechanisms of nicotinamide phosphoribosyl transferase (NAMPT) in the pathogenesis of psoriasis and to elucidate the effect of NAMPT on the nicotinamide adenine dinucleotide (NAD+) metabolic pathway in psoriasis.
Fanghua LIU +5 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber +15 more
wiley +1 more source