Results 71 to 80 of about 11,695 (173)

Recurrence-free survival by NAMPT IHC score.

, 2019
Kaplan-Meier curves showing recurrence-free survival of patients with NAMPT+ (blue line) and NAMPT- (red line) PDA. Median OS: 12.0 months (NAMPT+) vs. 13.5 months (NAMPT-); P-value: 0.34.
Po Hien Ear (6444044), Kimberly L. Cramer-Morales (6444038), Ann M. Miller (6444041), Sarah L. Mott (6444035), Katelynn Davis (6444029), Carlos H. F. Chan (37435), Andrew M. Bellizzi (6444047), Craig D. Dunseth (6444032), James J. Mezhir (499018)   +8 more
core   +1 more source

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

, 2009
Aims/hypothesis Extracellular pre-B cell colony-enhancing factor/nicotinamide phosphoribosyltransferase/visfatin (ePBEF/NAMPT/visfatin) is an adipocytokine, whose circulating levels are enhanced in metabolic disorders, such as diabetes mellitus and ...
Carraro, Raffaele, Rodríguez-Mañas, Leocadio, Sánchez-Ferrer, Carlos Félix, Matesanz, Nuria, Peiró, Concepción, Nevado, Julián, Cercas, Elena, Romacho, Tania, Azcutia Criado, Verónica, Vázquez-Bella, Marta   +9 more
core   +1 more source

NAMPT haploinsufficiency is a collateral lethal therapeutic vulnerability in high-risk myeloid malignancies with TP53 inactivation

Blood Neoplasia
: Monosomy 7 (−7) and deletions of chromosome arm 7q (del(7q)) are prevalent high-risk cytogenetic abnormalities that often co-occur with del(17p) (harboring TP53).
Madhavi D. Senagolage, Hunter Z. Blaylock, Saira Khan, Sarah J. Skuli, Martin P. Carroll, Megan E. McNerney   +5 more
doaj   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Visfatin/PBEF/Nampt: a new cardiovascular target? [PDF]

, 2010
In the last years, a growing interest has emerged towards understanding the role of adipocytokines in the development of cardiometabolic complications. Five years ago, visfatin/PBEF/Nampt was identified as a novel adipocytokine.
Carlos F Sánchez-Ferrer, Raffaele Carraro, Concepción Peiró, Tania eRomacho, Concepción ePeiró, Raffaele eCarraro, Tania Romacho, Carlos F. Sánchez-Ferrer   +7 more
core   +1 more source

Aerobic and resistance exercise training reverses age‐dependent decline in NAD+ salvage capacity in human skeletal muscle

Physiological Reports, 2019
Aging decreases skeletal muscle mass and strength, but aerobic and resistance exercise training maintains skeletal muscle function. NAD+ is a coenzyme for ATP production and a required substrate for enzymes regulating cellular homeostasis.
Roldan M. de Guia, Marianne Agerholm, Thomas S. Nielsen, Leslie A. Consitt, Ditte Søgaard, Jørn W. Helge, Steen Larsen, Josef Brandauer, Joseph A. Houmard, Jonas T. Treebak   +9 more
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Regulation of neutrophil function by NAMPT [PDF]

Neutrophils have capacity to cause tissue damage in chronic inflammatory disease. In rheumatoid arthritis (RA) they infiltrate joints, secrete proteases and reactive oxygen species (ROS), and express cytokines.
Roberts, Kate
core   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Regulation of Regenerative Periodontal Healing by NAMPT [PDF]

, 2013
Contains fulltext : 125845.pdf (Publisher’s version ) (Open Access)Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues.
Jepsen, S., Keser, S., James Deschner, Nokhbehsaim, M., Deschner, J., Sema Keser, Marjan Nokhbehsaim, Søren Jepsen, Jager, A., Andreas Jäger   +9 more
core   +2 more sources