Results 91 to 100 of about 11,695 (173)

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Quantification of Nampt mRNA

, 2013
. Total RNA was isolated from A. human pancreatic tissue or B. isolated human islets. NAMPT mRNA was quantified using a Nampt specific Taqman assay (Applied Biosystems/Life Technologies, Carlsbad, CA.) according to the manufacturer's instructions and ...
Shui Qing Ye (3623), Lesya Novikova (387866), Wayne V. Moore (387871), Pei Ying Tong (387862), Mark Clements (387864), Yun Yan (387870), Nataliya Kibiryeva (387868), Karen Kover (387861), Lisa Stehno-Bittel (387865), Dara Watkins (387863), Jacob Stuhlsatz (387869), Doug Bittel (387867)   +11 more
core   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy [PDF]

Photoactivated chemotherapy agents show a promising ability to kill cancer cells under the action of light, including those in chronic hypoxic conditions.
Jaap, Wildeman, Amy C, Harms, Bobby, Chau, Vadde, Ramu, Maxime , A. Siegler, V.E.van der, Noord, Sylvia, E.Le Dévédec, Lujiao, Huang, Lukas, Wijaya, Ludovic, Bretin, Selda, Abyar, Sylvestre, Bonnet, Kimberley, Belfor, Yurii, Husiev   +13 more
core   +2 more sources

Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Cell Death Discovery
Nicotinamide adenine dinucleotide (NAD⁺) is a critical coenzyme involved in cellular metabolism, energy balance, and various physiological processes.
Weijia Zhang, Haoyu Ren, Wangwang Chen, Bo Hu, Chao Feng, Peishan Li, Yufang Shi, Jiankai Fang   +7 more
doaj   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source

Co-localization of insulin, glucagon, and Nampt.

, 2013
Immunofluorescence image of an islet from an adult male stained for insulin, glucagon and Nampt. A: insulin staining (beta cells) using anti-insulin antibody (green). B: Glucagon was identified in the same islet (alpha cells) using anti-glucagon antibody
Shui Qing Ye (3623), Lesya Novikova (387866), Wayne V. Moore (387871), Pei Ying Tong (387862), Mark Clements (387864), Yun Yan (387870), Nataliya Kibiryeva (387868), Karen Kover (387861), Lisa Stehno-Bittel (387865), Dara Watkins (387863), Jacob Stuhlsatz (387869), Doug Bittel (387867)   +11 more
core   +1 more source

Bi-directional crosstalk between NAD/NAMPT and IFN-γ/PD-L1axes in melanoma

Targeted therapy and immune checkpoint inhibitors (ICIs) have notably improved the treatment of BRAF- mutated metastatic melanoma (MM) patients; however, resistance mechanisms dramatically impact on the survival of patients.
Rossana Piraino, Valentina Audrito, Anna Szumera-Ciećkiewicz, Gianna Baroni, Barbara de Cesaris, Daniela Massi, Irene Fiorilla, Filippo Ugolini, Vincenzo Calautti, Alberto Maria Todesco, Enrico Moiso   +10 more
core   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source