Results 111 to 120 of about 11,695 (173)

Structural insights into Xanthomonas campestris pv. campestris NAD+ biosynthesis via the NAM salvage pathway

Communications Biology
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) via the nicotinamide (NAM) salvage pathway. While the structural biochemistry of eukaryote NAMPT has been well studied,
Guolyu Xu, Jinxue Ma, Qi Fang, Qiong Peng, Xi Jiao, Wei Hu, Qiaoqiao Zhao, Yanqiong Kong, Fenmei Liu, Xueqi Shi, Dong-Jie Tang, Ji-Liang Tang, Zhenhua Ming   +12 more
doaj   +1 more source

NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation

, 2017
Recent studies have indicated a potential correlation between rheumatoid arthritis (RA) and periodontal inflammation. We undertook this study to verify whether RA mediates periodontitis-like phenotypes in experimental mouse models of RA and to explore ...
S. Kim, G. Lee, J. Koh, D. Kim, Y.H. Huh, S.Y. Lee, K.H. Park, J. Ryu, J. Kim   +8 more
core   +1 more source

Study on macrophage NAMPT function in inflammation-induced colon cancer

, 2023
MasterI. INTRODUCTION 1 II. MATERIALS AND METHODS 4 A. Antibodies and chemical reagents 4 B. Mice 4 C. Cell culture 5 D. DSS-induced colitis model 5 E. AOM/DSS-induced colorectal cancer model 5 F. Xenograft model 6 G.
이, 아연
core  

Visfatin/ Nampt: an adipokine with cardiovascular impact,”Mediators

, 2020
Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors termed adipokines. Visfatin was initially identified as a novel adipokine with insulin-mimetic properties in mice.
Carlos F Sánchez-Ferrer, Concepción Peiró, Tania Romacho   +2 more
core  

Inhibition of NAMPT by PAK4 Inhibitors

The serine/threonine kinase PAK4 plays a crucial role in regulating cell proliferation, survival, migration, and invasion. Overexpression of PAK4 correlates with poor prognosis in some cancers. KPT-9274, a PAK4 inhibitor, significantly reduces the growth
Audrey Minden, Yiling Wang
core   +1 more source

Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+ biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase activity (e.g., PARPs, SIRTs, CD38).
Isabella S. Krider (14576613), Megan S. Laham (14576610), Erick T. M. Alves (18321155), Gregory R. J. Thatcher (7942685), Jenna M. Courey (17637109), Ganga Reddy Velma (18321152)   +5 more
core   +1 more source

eNAMPT-IFITM3 axis links neuroinflammation to γ-secretase activation. [PDF]

iScience
Hyun J, Jung S, Noh Y, Cho Y, Saido TC, Nah J, Kim KW, Jung YK.   +7 more
europepmc   +1 more source

Aerobic exercise combined with FK866 ameliorates Alzheimer's disease-like pathology in APP/PS1 mice with NAMPT abnormality. [PDF]

Front Immunol
Sun C, Zhang T, Fan B, Zhang X, Zhao N.
europepmc   +1 more source

Parkinson's Disease: Immunometabolic Control Points Across Neural, Vascular, and Peripheral Systems. [PDF]

Parkinsons Dis
Narvaez Irizarry Felix Y, Bermudez Adorno Alondra M, Boris E, Lilia K, Mikhail I.   +4 more
europepmc   +1 more source

Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor. [PDF]

Acta Crystallogr D Struct Biol
Park J, Hong HR, Han SH, Song J, Son SY, Choi S, Park SM, Lee WK, Jiko C, Kim JH, Jee JG, Bang JK, Park IY, Lee SJ.   +13 more
europepmc   +1 more source