Results 101 to 110 of about 11,695 (173)

NAMPT: A critical driver and therapeutic target for cancer

, 2022
Nicotinamide phosphoribosyltransferase (NAMPT) possesses a vital role in mammalian cells due to its activity as a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide.
Massimiliano Gasparrini, Valentina Audrito, Audrito, Valentina, Gasparrini, Massimiliano   +3 more
core   +1 more source

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed and abundantly released from malignant pleural mesothelioma cells becoming a potential biomarker.

Introduction Malignant pleural mesothelioma (MPM) is an aggressive and incurable cancer of the pleural surface. Chronic inflammation, oxidative stress, and persistent aberrant signaling due to asbestos exposure led to mesothelial cells transformation ...
Francesca Mazzola, Valentina Audrito, Alessia Ponzano, Santina Bruzzone, Francesco Piacente, Roberta Libener, Irene Fiorilla, Federica Grosso, Nadia Raffaelli, Alberto Maria Todesco, Enrico Moiso   +10 more
core   +1 more source

Investigating the role of Nicotinamide phosphoribosyltransferase (NAMPT) in cartilage catabolism [PDF]

NAMPT (nicotinamide phosphoribosyltransferase) is a universally expressed protein elevated in the serum and synovial fluid of rheumatoid arthritis (RA) sufferers. NAMPT is a rate-limiting enzyme in the biosynthesis of (nicotinamide adenine dinucleotide)
Evans, Laura
core   +5 more sources

Nicotinamide phosphoribosyltransferase expression and clinical outcome of resected stage I/II pancreatic ductal adenocarcinoma.

PLoS ONE, 2019
BackgroundNicotinamide phosphoribosyltransferase (NAMPT) plays a key role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), which is a vital cofactor in redox reactions and a substrate for NAD+ consuming enzymes including CD38, PARPs and ...
Katelynn Davis, Craig D Dunseth, Sarah L Mott, Kimberly L Cramer-Morales, Ann M Miller, Po Hien Ear, James J Mezhir, Andrew M Bellizzi, Carlos H F Chan   +8 more
doaj   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase

Cell & Bioscience, 2017
Background Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis.
Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu, Shui Qing Ye   +8 more
doaj   +1 more source

NAMPT IHC score in PDA.

, 2019
NAMPT IHC score in PDA.
Po Hien Ear (6444044), Kimberly L. Cramer-Morales (6444038), Ann M. Miller (6444041), Sarah L. Mott (6444035), Katelynn Davis (6444029), Carlos H. F. Chan (37435), Andrew M. Bellizzi (6444047), Craig D. Dunseth (6444032), James J. Mezhir (499018)   +8 more
core   +1 more source

NAMPT regulates mitochondria and oxidative stress level for mouse early embryo development

Biological Research
Background Nicotinamide phosphoribosyltransferase (NAMPT) is an enzyme that involves into NMN-NAD + synthesis which involves into cellular metabolism related with aging, immune function, and neurodegeneration.
Mei-Hua Liao, Xin Liu, Xiao-Ting Yu, Shun Zhang, You-Zhu Li, Lin-Lin Hu, Shao-Chen Sun, Jun-Li Wang   +7 more
doaj   +1 more source

Single-Cell RNA sequencing identifies NAMPT as a potential therapeutic target in autoimmune uveitis

Journal of Advanced Research
Introduction: Autoimmune uveitis (AU) is an autoimmune disease of the eye that can lead to irreversible vision loss. Current therapies are limited by suboptimal efficacy and substantial side effects, highlighting the urgent need for the discovery of ...
Yingying Wen, Lei Zhu, Zhaohao Huang, Genxian Zhang, Shenqian Tian, Yue Peng, Yihan Zhang, Dongting Wu, Xuling Chen, Gengchen Jiang, Wenru Su, He Li   +11 more
doaj   +1 more source