Results 1 to 10 of about 374,259 (227)

Nicotinamide adenine dinucleotide (NAD+). Formal potential of the NAD+/NAD[middle dot] couple and NAD[middle dot] dimerization rate [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1984
The rate constant, kd, for the dimerization of the free radical (NAD[middle dot]), produced on the initial one-electron reduction of NAD+, was measured by double potential-step chronoamperometry, fast-scan cyclic voltammetry (cathodic-anodic peak current
Elving, Philip Juliber, Jensen, Mark A.
core   +3 more sources

Disrupting the Balance: Consequences of Sustained Subcellular NAD⁺ Depletion on Cellular Homeostasis [PDF]

Nature Metabolism
Nikotinamidadenindinukleotid (NAD⁺) spiller en avgjørende rolle i en lang rekke cellulære prosesser. Lavere NAD⁺-nivåer bidrar til patogenesen av aldringsrelaterte sykdommer og er en nøkkelfaktor i selve aldringsprosessen.
Høyland, Lena Elise
core   +3 more sources

Evidence for binding of NAD dimers to NAD-dependent dehydrogenases.

Biochimica et Biophysica Acta (BBA) - Enzymology, 1981
The binding of dimers of NAD, (NAD)2, to lactate, malate and alc. dehydrogenases was studied by the fluorescence quenching technique. Whereas alc. dehydrogenase shows a low binding ability, malate and lactate dehydrogenases bind (NAD)2 in a specific way
CASINI, Antonio, CARELLI, Vincenzo, AVIGLIANO L., FINAZZI AGRÒ A., LIBERATORE, Felice   +4 more
core   +4 more sources

CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice [PDF]

Diabetes & Metabolism Journal, 2023
Background CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung   +15 more
doaj   +1 more source

Conceptual framework for SARS-CoV-2–related lymphopenia

Advanced Biomedical Research, 2022
The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh, Shirin Kouhpayeh, Yadollah Azizi, Hossein Khanahmad   +3 more
doaj   +1 more source

“NAD-capQ” detection and quantitation of NAD caps [PDF]

RNA, 2018
RNA 5′ cap structures comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) have been identified in diverse organisms. Here we report a simple, two-step procedure to detect and quantitate NAD-capped RNA, termed “NAD-capQ.” By use of NAD-capQ we quantitate NAD-capped RNA levels in Escherichia coli, Saccharomyces cerevisiae, and human
Grudzien-Nogalska, Ewa, Bird, Jeremy G., Nickels, Bryce E., Kiledjian, Megerditch   +3 more
openaire   +2 more sources

Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages

Exploration of Immunology, 2023
Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk.
Rafael Moura Maurmann, Brenda Landvoigt Schmitt, Negin Mosalmanzadeh , Brandt D. Pence   +3 more
doaj   +1 more source

CD38 in Neurodegeneration and Neuroinflammation

Cells, 2020
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro, Anne-Laure Privat, Laurence Bressac, Damien Toulorge   +3 more
doaj   +1 more source

The investigation of the effect of NAD, H2O2 and weak magnetic field on the antibacterial mechanism of isoniazid (INH) that first line antibiotic against M. tuberculosis agent

Medicine Science, 2020
Tuberculosis is an infectious disease, which is caused by the Mycobacterium tuberculosis complex. This disease leads to up to 1.3 million deaths out of more than eight million cases every year.
Selami Gunal, Kadir Batcioglu, Esra Erdogan   +2 more
doaj   +1 more source

Enfermedad del coronavirus (covid-19) y las sirtuinas

Revista de la Facultad de Ciencias Médicas de Córdoba, 2020
Las  proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19 ...
Ronald Eleazar Huarachi Olivera, Antonio Lazarte Rivera   +1 more
doaj   +1 more source