Results 41 to 50 of about 184,095 (185)

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

open access: yesThe FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon   +6 more
wiley   +1 more source

AMERICAN MULTI-DWELLING ARCHITECTURE OF THE SECOND HALF OF THE 19TH CENTURY AND FIRST HALF OF THE 20TH CENTURY [PDF]

open access: yesAR: Arhitektura, Raziskave, 2013
At the end of the 19th and beginning of the 20th century, the evolution of American multiple-dwelling architecture was marked by the passage from the standard construction of single-family standalone homes and row houses to a new housing typology which ...
Srđan Nađ
doaj  

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

open access: yesClinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Loss of intestinal epithelial fucosylation exacerbates alcohol‐related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol‐induced intestinal ...
Liuying Chen   +9 more
wiley   +1 more source

Threat of Pollution Hotspots Reworking in River Systems: Case Study of the Ploučnice River (Czech Republic)

open access: yesISPRS International Journal of Geo-Information, 2019
As fluvial pollution may endanger the quality of water and solids transported by rivers, mapping and evaluation of historically polluted fluvial sediments is an urgent topic.
Jitka Elznicová   +5 more
doaj   +1 more source

Maternal Circulatory NAD Precursor Levels and the Yolk Sac Determine NAD Deficiency‐Driven Congenital Malformation Risk

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Maternal circulatory L‐tryptophan (TRP) and nicotinamide (NAM) levels are proportional to dietary TRP intake. Yolk sacs, but not embryos, perform NAD de novo synthesis. This study explores the exchange of NAD precursors between mother and conceptus, and NAD generation in conceptal tissues via the NAD de novo synthesis (blue) or salvage (red) pathways ...
Kayleigh Bozon   +6 more
wiley   +1 more source

Structural dynamic modification of vibrating systems [PDF]

open access: yesApplied and Computational Mechanics, 2007
Vibration and acoustic requirements are becoming increasingly important in the design of mechanical structures. The need to vary the structural behaviour to solve noise and vibration problems occurs at design or prototype stage, giving rise to the so ...
Naď M.
doaj  

Effects of Aging on Glucose and Lipid Metabolism in Mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien   +8 more
wiley   +1 more source

Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?

open access: yesBrain Sciences, 2020
Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this ...
Petr Kelbich   +9 more
doaj   +1 more source

Corporate Social Responsibility of Organizations as Part of a Quality Management System

open access: yesProduction Engineering Archives, 2021
The paper deals with the topic of social responsibility in selected organizations in the Czech Republic. This topic is mainly associated with the requirements for economical and ecological production.
Střihavková Elena   +2 more
doaj   +1 more source

Optimization of 1H‐MRS methods for large‐volume acquisition of low‐concentration downfield resonances at 3 T and 7 T

open access: yesMagnetic Resonance in Medicine, Volume 93, Issue 1, Page 18-30, January 2025.
Abstract Purpose This goal of this study was to optimize spectrally selective 1H‐MRS methods for large‐volume acquisition of low‐concentration metabolites with downfield resonances at 7 T and 3 T, with particular attention paid to detection of nicotinamide adenine dinucleotide (NAD+) and tryptophan.
Neil E. Wilson   +5 more
wiley   +1 more source

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