Results 81 to 90 of about 11,695 (173)

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Die Regulation von Nampt nach Myokardinfarkt [PDF]

, 2014
Das Protein Nampt wurde in der Literatur bereits mehrfach als protektiver Ein-flussfaktor im Zusammenhang mit dem Schutz vor Apoptose von Kardiomyozy-ten sowie der Förderung von Angiogenese von Endothelzellen beschrieben.
Jores, Kristina
core   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors

, 2013
: Nicotinamide phoshophoribosyltransferase (NAMPT) plays a key role in the replenishment of the NAD pool in cells. This in turn makes this enzyme an important player in bioenergetics and in the regulation of NAD-using enzymes, such as PARPs and sirtuins.
Massarotti A., Galli U., Rahimian R., Tron G. C., Genazzani A. A., Travelli C., Fakhfouri G.   +6 more
core   +1 more source

NAMPT (nicotinamide phosphoribosyltransferase) [PDF]

, 2012
Review on NAMPT (nicotinamide phosphoribosyltransferase), with data on DNA, on the protein encoded, and where the gene is ...
Dalamaga, M, Koumaki, V
core   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis

Acta Neuropathologica Communications
Nicotinamide adenine dinucleotide (NAD+) plays an important role in tumor progression, but its role in non-small cell lung cancer with brain metastasis (NSCLC BM) remains unclear.
Liyun Zhou, Zhiying Li, Shengli Zhou, Bin Wang, Zhen Liang, Sen Hu, Hang Zhang, Lin Duan, Dongxu Zhao, Luyao Cheng, Hang Ren, Hiroaki Wakimoto, Ming Li   +12 more
doaj   +1 more source

NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter

Frontiers in Cell and Developmental Biology, 2020
Obesity has become a serious problem in public health worldwide, causing numerous metabolic diseases. Once the differentiation to mature adipocytes is disrupted, adipocyte hypertrophy and ectopic lipid accumulation leads to the inflammation in adipose ...
Keisuke Okabe, Keisuke Okabe, Allah Nawaz, Allah Nawaz, Yasuhiro Nishida, Keisuke Yaku, Isao Usui, Kazuyuki Tobe, Kazuyuki Tobe, Takashi Nakagawa, Takashi Nakagawa   +10 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Gene-gene interactions in the NAMPT pathway, plasma visfatin/NAMPT levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy

, 2017
Nicotinamide phosphorybosil transferase (NAMPT) polymorphisms affect visfatin/NAMPT levels and may affect the responsiveness to therapy in hypertensive disorders of pregnancy.
Amaral, L. M., Belo, V. A., Tanus-Santos, J. E., Duarte, G., Sandrim, V. C. [UNESP], Palei, A. C.T., Cavalli, R. C., Lacchini, R., Luizon, M. R.   +8 more
core   +1 more source