Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
Cells, 2023 Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis.
Dao-Xin Wang +8 more
doaj +1 more source
NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children. [PDF]
PLoS ONE, 2017 Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood.
Julia Gesing +7 more
doaj +1 more source
Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small-Cell Lung Cancer Models. [PDF]
Cancer SciDietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Tsurumi K +12 more
europepmc +2 more sources
Structural elements determining NAMPT activity [PDF]
, 2023 Nikotinamidadenindinukleotid (NAD) er en hydridbærer involvert i redoksreaksjoner i metabolismen. I tillegg er NAD+ et substrat av enzymer som medierer vitale NAD+-avhengige prosesser, der dinukleotidet spaltes, og frigjør en nikotinamiddel (Nam ...
Houry, Dorothée
core +1 more source
Journal of Translational Medicine, 2022 Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different
Valentina Audrito +12 more
doaj +1 more source
The influence of age on the responses of serum visfatin and insulin resistance to a single session of endurance exercise [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2013 Purpose: The purpose of this study was to investigate the effects of age on the responses of serum visfatin and insulin resistance index to a single session of endurance exercise.
هیوا رحمانی +3 more
doaj +1 more source
Antioxidants, 2022 Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD+ pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages.
Jae-Sung Kim +9 more
doaj +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Exposure to nanographene oxide induces gene expression dysregulation in normal human astrocytes
Endocrine Regulations, 2022 Objective. Nanographene oxide, an oxidation derivative of graphene, is considered to be one of the nanomaterials attractive for biomedical applications, although this nanomaterial is toxic.
Rudnytska Olha V. +8 more
doaj +1 more source
Regulation of NAMPT in human gingival fibroblasts and biopsies [PDF]
, 2014 Adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), are molecules, which are produced in adipose tissue. Recent studies suggest that NAMPT might also be produced in the tooth-supporting tissues, that is, periodontium, which also includes ...
Götz, Werner +17 more
core +3 more sources