Results 11 to 20 of about 11,695 (173)

NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.

PLoS ONE, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD)+ biosynthesis. Through its NAD+-biosynthetic activity, NAMPT influences the activity of NAD+-dependent enzymes, such as sirtuins.
Xiwen Xiong, Jiahui Yu, Rui Fan, Cuicui Zhang, Lin Xu, Xupeng Sun, Yanmei Huang, Qingzhi Wang, Hai-Bin Ruan, Xinlai Qian   +9 more
doaj   +2 more sources

Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis

Hereditas
Background Nicotinamide phosphoribosyltransferase (Nampt) is required for recycling NAD+ in numerous cellular contexts. Morpholino-based knockdown of zebrafish nampt-a has been shown to cause abnormal development and defective hematopoiesis concomitant ...
Autumn Penecilla Pomreinke, Patrick Müller   +1 more
doaj   +3 more sources

NAMPT haploinsufficiency is a therapeutic vulnerability to NAMPT inhibition in -7/-7q MDS [PDF]

Biomarker Research
Chromosome 7 abnormalities -7 and -7q define a high-risk subset of myelodysplastic syndromes (MDS) with poor prognosis. The NAMPT gene, located at 7q22.3, encodes a rate limiting enzyme (nicotinamide phosphoribosyl transferase) in the NAD+ salvage ...
Nemo Ikonen, Tanja Ruokoranta, Salla Hyyppä, Ella Sinervuori, Juho J. Miettinen, Joseph Saad, Markus Vähä-Koskela, Caroline A. Heckman   +7 more
doaj   +2 more sources

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells [PDF]

Mediators of Inflammation, 2013
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as ...
Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner   +9 more
doaj   +3 more sources

Expression and regulation of nampt in human islets. [PDF]

PLoS ONE, 2013
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD+ biosynthesis of a salvage pathway and exists in 2 known forms, intracellular Nampt (iNampt) and a secreted form, extracellular Nampt (eNampt).
Karen Kover, Pei Ying Tong, Dara Watkins, Mark Clements, Lisa Stehno-Bittel, Lesya Novikova, Doug Bittel, Nataliya Kibiryeva, Jacob Stuhlsatz, Yun Yan, Shui Qing Ye, Wayne V Moore   +11 more
doaj   +2 more sources

The nicotinamide phosphoribosyltransferase inhibitor FK866 restricts influenza A virus replication by perturbing viral polymerase activity [PDF]

Journal of Virology
Nicotinamide phosphoribosyltransferase (NAMPT), a key rate-limiting enzyme in NAD+ synthesis, plays important roles in various physiological and pathological processes.
Changjie Lv, Shuang Wang, Mingyue Song, Jianmei Wu, Wanxin Wei, Guijie Guo   +5 more
doaj   +2 more sources

NAMPT Inhibition Induces Neuroblastoma Cell Death and Blocks Tumor Growth

Frontiers in Oncology, 2022
High-risk neuroblastoma (NB) portends very poor prognoses in children. Targeting tumor metabolism has emerged as a novel therapeutic strategy. High levels of nicotinamide-adenine-dinucleotide (NAD+) are required for rapid cell proliferation. Nicotinamide
Frederic A. Vallejo, Anthony Sanchez, Anthony Sanchez, Branko Cuglievan, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Steven Vanni, Steven Vanni, Regina M. Graham, Regina M. Graham   +11 more
doaj   +2 more sources

Visfatin/Nampt: An Adipokine with Cardiovascular Impact [PDF]

Mediators of Inflammation, 2013
Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors termed adipokines. Visfatin was initially identified as a novel adipokine with insulin-mimetic properties in mice.
Tania Romacho, Carlos F. Sánchez-Ferrer, Concepción Peiró   +2 more
doaj   +2 more sources

Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells [PDF]

PeerJ, 2021
Background. Multiple studies have indicated crucial roles of NAD+ deficiency in several neurological diseases and aging. It is critical to discover the mechanisms underlying the NAD+ deficiency. A decreased level of Nicotinamide phosphoribosyltransferase
Cuiyan Zhou, Weihai Ying
doaj   +2 more sources

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

Acta Pharmaceutica Sinica B, 2022
Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation.
Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang, Chunquan Sheng   +5 more
doaj   +1 more source