Results 31 to 40 of about 11,695 (173)

LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis

Cancer Biology & Therapy, 2023
Cisplatin resistance is a major therapeutic challenge in non-small cell lung cancer (NSCLC). Herein, the regulatory role of long non-coding RNA (lncRNA) ITGB2-AS1 in regulating NSCLC cisplatin resistance was investigated. NSCLC cisplatin resistance cells
Huiyong Chen, Linhui Wang, Jingting Liu, Zihao Wan, Lin Zhou, Hongliang Liao, Renping Wan   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD⁺ biosynthesis. [PDF]

Mol Oncol
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Oh MJ, Jang JY, Jeon Y, Kim GC, Lee H, Lee J, Kim JH, Kim H, Kim M, Kwon HK, Lee H, Kim HS.   +11 more
europepmc   +2 more sources

Expression, Function and Bioinformatic Analysis of Nicotinamide Phosphoribosyl Transferase in Colon Cancer

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of nicotinamide phosphoribosyl transferase(NAMPT) in colon cancer tissues and analyze its physicochemical properties, secondary and tertiary structures, protein-protein interaction, subcellular localization and ...
TANG Jun, LIU Liming
doaj   +1 more source

Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Cell Communication and Signaling, 2020
Background The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood.
Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen, Shu Zheng   +8 more
doaj   +1 more source

Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples

Frontiers in Immunology, 2022
Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as a therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating NAMPT to perpetuate inflammation are yet to ...
Ming Lei, Meng-Qing Tao, Meng-Qing Tao, Yi-Jin Wu, Yi-Jin Wu, Liang Xu, Zhe Yang, Yan Li, Yan Li, Opeyemi Joshua Olatunji, Xiao-Wan Wang, Jian Zuo, Jian Zuo, Jian Zuo   +13 more
doaj   +1 more source

Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. [PDF]

PLoS ONE, 2013
A number of cancers show increased expression of Nicotinamide phosphoribosyl transferase (Nampt). However, the mechanism through which Nampt is upregulated is unclear.
Chenpeng Zhang, Jinlu Tong, Gang Huang
doaj   +1 more source

NAMPT in drug-resistant melanoma: linking NAMPT-dependent metabolic reprogramming and immune regulation

, 2023
Introduction Targeted-therapy and immune checkpoint inhibitors (ICIs) have notably improved the treatment of BRAF-mutated metastatic melanoma (MM) patients; however resistance to treatment dramatically impacts on the survival of patients.
Valentina Audrito., Vincenzo Calautti., Luca Ponzone., Rossana Piraino., Sara Sdelci., Alessia Ponzano., Alberto Maria Todesco., Irene Fiorilla., Enrico Moiso., Marcello Manfredi.   +9 more
core   +1 more source

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. [PDF]

PLoS ONE, 2008
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide.
Nathalie Busso, Mahir Karababa, Massimo Nobile, Aline Rolaz, Frédéric Van Gool, Mara Galli, Oberdan Leo, Alexander So, Thibaut De Smedt   +8 more
doaj   +1 more source

ZY NAMPT raw data

, 2023
ZY NAMPT raw ...
Yang Zhang (12980225)
core   +1 more source

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy

Cell Reports, 2019
Summary: Nicotinamide adenine dinucleotide (NAD+) metabolism plays a critical role in kidneys. We previously reported that decreased secretion of a NAD+ precursor, nicotinamide mononucleotide (NMN), from proximal tubules (PTs) can trigger diabetic ...
Hirokazu Muraoka, Kazuhiro Hasegawa, Yusuke Sakamaki, Hitoshi Minakuchi, Takahisa Kawaguchi, Itaru Yasuda, Takeshi Kanda, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh   +9 more
doaj   +1 more source