Results 51 to 60 of about 2,034 (179)
NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. [PDF]
PLoS ONE, 2014 Functional morphodynamic behavior of differentiated macrophages is strongly controlled by actin cytoskeleton rearrangements, a process in which also metabolic cofactors ATP and NAD(H) (i.e. NAD+ and NADH) and NADP(H) (i.e.
Gerda Venter +5 more
doaj +1 more source
The effect of FK866 on RAW 264.7 metabolism.
, 2014 A, B, Glucose consumption and lactate production in the presence and absence of FK866. Cells were incubated in control or FK866 medium for a total of 24 hours. Glucose and lactate was measured in medium supernatants collected over the last 6 hours (18–24
Mietske Wijers (368991) +5 more
core +1 more source
Porcine placental extract increase the cellular NAD levels in human epidermal keratinocytes
Scientific Reports, 2022 Nicotinamide adenine dinucleotide (NAD) is an essential cofactor for numerous enzymes involved in energy metabolism. Because decreasing NAD levels is a common hallmark of the aging process in various tissues and organs, maintaining NAD levels has ...
Takeshi Katayoshi +4 more
doaj +1 more source
The Effect of Visfatin on the Functioning of the Porcine Pituitary Gland: An In Vitro Study
Cells, 2023 Visfatin (VIS), also known as nicotinamide phosphoribosyltransferase (NAMPT), is the rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Recently, VIS has been also recognized as an adipokine. Our previous study revealed
Karolina Szymanska +13 more
doaj +1 more source
PARP inhibitors and sirtinol attenuate FK866-induced T cell demise.
, 2013 A, PBLs were cultured for 24 h with or without PHA. Thereafter, Nampt and PARP1 levels were detected by Q-PCR. mRNA levels in PHA-stimulated cells were compared to those in unstimulated PBLs.
Eva Moran (212204) +18 more
core +1 more source
Lipids in Health and Disease, 2017 Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is characterized with lipid accumulation in liver. Nicotinamide phosphoribosyltransferase
Ling-Fang Wang +8 more
doaj +1 more source
Advanced Science, EarlyView.Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang +12 more
wiley +1 more source
, 2022 Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge.
Jing Wang (6206297) +11 more
core +1 more source
Deciphering mechanisms of resistance to FK866 in cancer cells
, 2023 Nicotinamide phosphoribosyltransferase (NAMPT) is a key metabolic enzyme in NAD+ synthesis pathways which is found upregulated in several tumors, depicting NAD(H) lowering agents, as the NAMPT inhibitor FK866, an appealing approach for anticancer therapy.
openaire +1 more source
Frontiers in Immunology, 2022 Visfatin, a multifunctional adipocytokine, is particularly important in the regulation of apoptosis and inflammation through an unidentified mechanism. Clarifying the control mechanisms of visfatin on inflammation and apoptosis in RAW264.7 cells and mice
Zhewei Zhang +11 more
doaj +1 more source