Results 71 to 80 of about 2,034 (179)
Nucleotide Metabolism in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
wiley +1 more source
Inhibiting Nampt using FK866 increased cell senescence in MSCs obtained from the young group.
, 2017 Cells were treated with 10 nM FK866 for 72 h. (A) Unlike the controls, which displayed normal morphologies, the MSCs treated with FK866 were flattened and enlarged and displayed senescence-like morphological features.
Chenchen Pi (3710137) +7 more
core +1 more source
, 2022 Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge.
Jing Wang (6206297) +11 more
core +1 more source
Frontiers in Pharmacology, 2021 Opioids are a potential adjuvant treatment for certain cancers; while they are primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly used in China, but its effects on cancer
Chenyang Xue +10 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
, 2022 Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge.
Jing Wang (6206297) +11 more
core +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni +3 more
wiley +1 more source
, 2013 A, PHA- stimulated PBLs were incubated with 33 nM FK866 and ΔΨm was determined at the indicated days of exposure. B, Resting of PHA-stimulated PBLs were cultured with 33 nM FK866 for five days.
Eva Moran (212204) +18 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng +10 more
wiley +1 more source
, 2022 Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge.
Jing Wang (6206297) +11 more
core +1 more source