Results 91 to 100 of about 2,034 (179)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

Lipids in Health and Disease, 2017
Background Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose
Melanie Penke, Susanne Schuster, Theresa Gorski, Rolf Gebhardt, Wieland Kiess, Antje Garten   +5 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

The role of visfatin in prostate cancer [PDF]

The aim of this study was to investigate the role of the adipokine visfatin as a possible molecular mediator between obesity and prostate cancer. Visfatin, an adipokine that is elevated in obesity and has many proposed roles and has been linked to a ...
Patel, Snehal T.
core  

Lipopolysaccharides Modulate Cellular Responses in Dental Pulp Cells

International Journal of Dentistry, Volume 2026, Issue 1, 2026.
Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper understanding of its mechanisms.
Tanida Srisuwan, Chatvadee Kornsuthisopon, Nunthawan Nowwarote, Xiaofei Zhu, Waruna Lakmal Dissanayaka, Thanaphum Osathanon, Hannah Wesley   +6 more
wiley   +1 more source

Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Cell Communication and Signaling, 2020
Background The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood.
Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen, Shu Zheng   +8 more
doaj   +1 more source

Spatiotemporal Heterogeneity of Macrophages in Acute Pancreatitis: From Inflammatory Initiators to Repair Coordinators and Targeted Therapeutics

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
The current management of acute pancreatitis (AP) primarily relies on supportive measures, such as fluid resuscitation, nutritional support, and infection control. However, these approaches do not adequately address the core drivers of the disease. This limitation arises from an incomplete understanding of the progression from local injury to systemic ...
Xiang Lu, Yu Zeng, Li-hong Gan, Li Li, Jian-qin Liu, Xin Zhou, Xiao-ning Jin, Chao-li Jiang, Zhi Li, Zoltan Rakonczay Jr.   +9 more
wiley   +1 more source

Nampt inhibition with FK866 prevents T lymphocyte proliferation and selectively kills activated T cells.

, 2013
A, PBLs were seeded in 96-well plates in the presence or absence (unstim.) of PHA and 33 nM FK866. Proliferation was assessed 96 h later by standard [3H]thymidine incorporation assay. B, PBLs were incubated in 96-well plates in the presence or absence of
Eva Moran (212204), Tiziana Ferrando (369236), Martina Selmo (369238), Alberto Ballestrero (212236), Alessio Nencioni (212243), Debora Soncini (212187), Antonio Uccelli (8756), Floriana Fruscione (176224), Alessandro Poggi (224324), Federica Benvenuto (369239), Sara Morando (369232), Santina Bruzzone (212241), Anna Garuti (212195), Bernard Sordat (369240), Agustina D'Urso (369237), Michele Cea (212184), Franco Patrone (212239), Gabriele Zoppoli (201733), Raul Mostoslavsky (369241)   +18 more
core   +1 more source

Olaparib sensitivity in FK866-treated C1/OLA cells.

C1/OLA cells were treated with 4.5 nM FK866 and 0–50 μM olaparib, and then cell viability was measured by CCK assay. (TIF)
Ryusuke Nakatsuka (15114715), Amane Inoue (18388093), Mitsuko Masutani (78971), Takuma Inouchi (18388090), Yuka Sasaki (140958), Tadashige Nozaki (78965)   +5 more
core   +1 more source

Dual Roles of Canagliflozin on Cholangiocarcinoma Cell Growth and Enhanced Growth Suppression in Combination with FK866

International Journal of Molecular Sciences
Cholangiocarcinoma-associated mortality has been increasing over the past decade. The sodium-glucose cotransporter 2 inhibitor, canagliflozin, has demonstrated anti-tumor effects against several types of cancers; however, studies examining its potential impact on cholangiocarcinoma are lacking.
Daisuke Taguchi, Yohei Shirakami, Hiroyasu Sakai, Daisuke Minowa, Takao Miwa, Toshihide Maeda, Masaya Kubota, Kenji Imai, Takashi Ibuka, Masahito Shimizu   +9 more
openaire   +4 more sources