Results 101 to 110 of about 2,034 (179)
Redox BiologyUterine leiomyoma (UL), commonly referred to as benign tumors, is characterized by excessive cell proliferation, extracellular matrix (ECM) accumulation, and the presence of stem cell-like properties.
Yi-Fen Chiang +7 more
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Synthetic lethality of PARP and NAMPT inhibition in triple‐negative breast cancer cells
EMBO Molecular Medicine, 2012 PARP inhibitors have been proposed as a potential targeted therapy for patients with triple‐negative (ER‐, PR‐, HER2‐negative) breast cancers. However, it is as yet unclear as to whether single agent or combination therapy using PARP inhibitors would be ...
Ilirjana Bajrami +6 more
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, 2014 Figure S3: Cells were treated for one, two or three days with FK866 at 1 nM, 10 nM and 50 nM. A) AMPK was phosphorylated at all concentrations at day 1, but only at 1 nM after three days incubation with FK866. B) mTOR was phosphorylated at 1 nM and 10 nM
Spencer B. Gibson (10713717) +6 more
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Enhancing the anticancer effect of NAMPT inhibition by targeting NAPRT in breast cancer cells
Advances in Cancer Biology - MetastasisIntroduction: Two pathways in the synthesis of NAD, catalyzed by the key enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), support constant survival, growth, and propagation of cancer cells.
Zahra Gharedaghi +6 more
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Effects of FK866 and EX527 on p53 acetylation and cell viability in HepG2 cells.
, 2014 Cells were stimulated with FK866 [10 nM] or EX527+TSA [20 µM EX527+1 µM TSA] in serum-free medium (con). Cells treated with A) FK866 and expression of acetylated p53 (K382) after 24 h.
Wieland Kiess (102793) +7 more
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A549 clonal cell population sensitivity to FK866 (5 nM) before and after IDO induction.
, 2015 Proliferation of each of 5 individual A549 cell clonal populations before (Panel A) and after (Panel B) IDO induction with IFNγ. A549 clonal cell populations were cultured with or without IFNγ (25 ng/ml) for 48 h.
Di Chen (15424) +10 more
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HaematologicaIntroduction. Multiple myeloma (MM) is an incurable hematologic malignancy characterized by progressive metabolic reprogramming that accompanies disease evolution. During relapse, MM cells frequently acquire drug resistance, underscoring the need for new
Isabella Traverso
doaj
, 2013 A. Cells were treated with different concentrations of FK866 for 72 h and then evaluated by using Cell Counting Kit-8. The IC50 values were calculated. Each assay was repeated at least 3 times. B.
Jinlu Tong (438902) +2 more
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Nam and Na prevent NAD+ shortage and cell death induced by FK866 in human T lymphocytes.
, 2013 A, PHA-stimulated PBLs were treated (or not) with 33 nM FK866 in the presence or absence of 10 mM Nam or of 10 µM Na. After 48 h, NAD+ content was determined (expressed as percentage of NAD+ content in FK866-untreated cells). B, PBLs were cultured for 24
Eva Moran (212204) +18 more
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Molecular CancerRecent research has uncovered a surprisingly high occurrence of aberrant expression and mutations in the genes that encode subunits of the SWI/SNF chromatin-remodeling complexes (SCRC).
Kai Zhuang +9 more
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