Results 111 to 120 of about 2,034 (179)

Inhibition of NAD⁺ salvage synthesis with FK866 does not affect proliferation or viability of macrophages.

, 2014
A, B, RAW 264.7 and Maf-KDO proliferation in the presence of different concentrations of FK866, monitored by measuring the increase in protein mass at different intervals over a 24 or 72 hour period.
Mietske Wijers (368991), Marieke Willemse (359989), Jack A. M. Fransen (266060), Frank T. J. J. Oerlemans (559405), Bé Wieringa (42792), Gerda Venter (559404)   +5 more
core   +1 more source

FK866 reduces axon pathology in in vitro and in vivo models of Huntington’s disease and Alzheimer’s disease and attenuates behavioral abnormalities [PDF]

Among its various biological functions, NAD metabolism regulates axon degeneration, which is an early and often causative event in a variety of neurodegenerative diseases including Huntington’s disease (HD) and Alzheimer’s disease (AD).
Othman, Othman Ahmad
core   +3 more sources

FK866 reduces axon pathology in in vitro and in vivo models of Huntington’s disease and Alzheimer’s disease and attenuates behavioral abnormalities [PDF]

, 2016
Among its various biological functions, NAD metabolism regulates axon degeneration, which is an early and often causative event in a variety of neurodegenerative diseases including Huntington’s disease (HD) and Alzheimer’s disease (AD).
Othman, Othman Ahmad
core  

Targeting the NAD+ Salvage Pathway Blocks Metabolic Recovery and Enhances β-Lapachone Toxicity in NQO1-Expressing Glioblastoma Cells. [PDF]

Cancer Res Commun
Chang-Gu B, Baljinnyam T, Sowers ML, Dilawari R, Herring J, Sowers L.   +5 more
europepmc   +1 more source

Artificial Intelligence-Guided Prioritization and Experimental Evaluation of Synergistic Target Combinations for Breast Cancer Therapy. [PDF]

Pharmaceuticals (Basel)
Feng C, Feng Q, She S, Yang R, Li M, Gong L, Rui M.   +6 more
europepmc   +1 more source

Beyond NAD Depletion: SARM1-Induced ATP Collapse Involves Direct ATP Degradation and Mitochondrial Dysfunction and Is Pharmacologically Reversible. [PDF]

Biology (Basel)
Chen Z, Zhao ZY, Zhang ZM, Zhao R, Shen L, Lee HC, Fang L, Zhao YJ.   +7 more
europepmc   +1 more source

Placental nicotinamide adenine dinucleotide modulates the timing of labor. [PDF]

Science
Ciampa EJ, Machado LM, Lee KJ, Clark AJ, Vu KQ, Khan NA, Kispert S, Armstrong S, Li Y, Milne GL, Solmonson A, Karumanchi SA, Parikh SM.   +12 more
europepmc   +1 more source

Ion-coupled transfersome complexes for enhanced transdermal NAD⁺ repletion and mitigation of cellular senescence signatures. [PDF]

Mater Today Bio
Kang S, Wei S, Koo BI, Jo Y, Park J, Xue Y, Ye S, Park J, Hwang BW, Kim JH, Jeong E, Kim J, Kang NG, Jun SH, Ryu D.   +14 more
europepmc   +1 more source

NAD⁺ controls circadian rhythmicity during cardiac aging. [PDF]

Commun Biol
Carpenter BJ, Lecacheur M, Mangold YN, Cui K, Günther S, Vermunt MW, Dierickx P.   +6 more
europepmc   +1 more source

Pharmacophore-Based QSAR Model of Multi Scaffolds as NAMPT Inhibitors & Scaffold Diversity Analysis. [PDF]

Molecules
Lee S, Zheng M, Kim K, Chun KH.
europepmc   +1 more source