Results 81 to 90 of about 2,034 (179)

Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment

Oncotarget, 2018
Cross-resistance to drugs remains an unsolved problem in cancer chemotherapy. This study elucidates a molecular mechanism of cross-resistance to diverse inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) with anticancer activity. We generated a variant of the human colon cancer cell line HCT116, HCT116RFK866, which exhibited primary ...
Ogino, Yoko, Sato, Akira, Uchiumi, Fumiaki, Tanuma, Sei-ichi   +3 more
openaire   +3 more sources

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells [PDF]

Journal of Biological Chemistry, 2013
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first reaction in the "salvage" pathway from nicotinamide, showed potent antitumor activity in several ...
GROZIO, ALESSIA, SOCIALI, GIOVANNA, STURLA, LAURA, CAFFA, IRENE, SONCINI, DEBORA, SALIS, ANNALISA, Raffaelli N, DE FLORA, ANTONIO, NENCIONI, ALESSIO, BRUZZONE, SANTINA   +9 more
openaire   +3 more sources

CIAdex: Label‐Free Cell Identification and Aging Quantification Using Single‐Cell Infrared Spectral Fingerprints

Advanced Photonics Research, Volume 7, Issue 4, April 2026.
Cell Identification and Aging Index (CIAdex) harnesses single‐cell infrared spectral fingerprints to provide label‐free cell identification and quantitative aging assessment. By integrating machine learning with Fourier‐transform infrared (FTIR) microspectroscopy, this framework distinguishes cell types, donors, and batches while tracking aging ...
Ying Wang, Yanfei Ding, Chengzhang He, Xiaojie Zhou, Junwu Tu, Yulei Deng, Jian Zhao   +6 more
wiley   +1 more source

Nicotinamide Administration Improves Remyelination after Stroke

Neural Plasticity, 2017
Aims. Stroke is a leading cause of morbidity and mortality. This study aimed to determine whether nicotinamide administration could improve remyelination after stroke and reveal the underlying mechanism. Methods.
Congxiao Wang, Yi Zhang, Jie Ding, Zhen Zhao, Cheng Qian, Ying Luan, Gao-Jun Teng   +6 more
doaj   +1 more source

Multi‐Omics Analysis of TYMS as a Prognostic Biomarker and Therapeutic Target for Lung Adenocarcinoma

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung adenocarcinoma (LUAD) is a predominant form of lung cancer with poor prognosis due to early diagnosis challenges and treatment resistance. Thymidylate synthetase (TYMS), a key enzyme in DNA synthesis, has been associated with poor prognosis in multiple cancers, yet its multi‐omics characteristics in LUAD remain systematically ...
Hansen Shi, Peijun Zhang, Jiayi Chen, Hua Li, Xiaohuai Zhang, Biyun zeng, Tiancai Liu, Tao Zeng   +7 more
wiley   +1 more source

NAD⁺, NMN, and NADP⁺ supplementation stimulate phagocytosis and give reversal of FK866 effects.

, 2014
Cells were incubated for 24 hours with 100 µM NAD+, 100 µM NMN or 50 µM NADP+ in the presence or absence of 5 nM FK866 and activated overnight with LPS before they were incubated with FITC-labeled complement opsonized zymosan (COZ) particles for 30 min ...
Mietske Wijers (368991), Marieke Willemse (359989), Jack A. M. Fransen (266060), Frank T. J. J. Oerlemans (559405), Bé Wieringa (42792), Gerda Venter (559404)   +5 more
core   +1 more source

The NAMPT Inhibitor FK866 Attenuates DEN-Induced Liver Fibrosis in Mice

Biological and Pharmaceutical Bulletin
Chronic liver disease (CLD) poses a significant global health challenge, and liver fibrosis is a crucial process in the pathogenesis of CLD. However, effective interventions to halt and reverse the progression of liver fibrosis remain elusive. This study investigated the potential of the nicotinamide phosphoribosyltransferase (NAMPT) inhibitor FK866 in
Ren, Daocun, Wang, Siyang, Li, Longhui, Fan, Zhiwen, Li, Mingnan, Li, Longjiang   +5 more
openaire   +2 more sources

Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. [PDF]

PLoS ONE, 2012
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme for nicotinamide adenine dinucleotide (NAD) biosynthesis, and can be found either intracellularly (iNAMPT) or extracellularly (eNAMPT).
Li-Ying Liu, Feng Wang, Xia-Yan Zhang, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Wei-Ping Zhang   +6 more
doaj   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil

Oncology Reports, 2011
Nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in the NAD⁺ salvage pathway, is over-expressed and important in the carcinogenesis in several types of cancers. The expression of Nampt and its role in gastric cancer remain largely unknown. In this study, using real-time PCR and Western blotting we found that Nampt was overexpressed at
Tie-Qiang, Bi, Xiang-Ming, Che, Xin-Hua, Liao, Dan-Jie, Zhang, Hou-Long, Long, Hai-Jun, Li, Wei, Zhao   +6 more
openaire   +3 more sources