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Chromosomal assignment of the human immunophilin FKBP-12 gene
Biochemical and Biophysical Research Communications, 1991FKBP-12 is the major T cell binding protein for the immunosuppressive drugs FK506 and rapamycin. It is a member of the immunophilin family of proteins which are believed to play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.
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FK506 AND THE ROLE OF THE IMMUNOPHILIN FKBP-52 IN NERVE REGENERATION*
Drug Metabolism Reviews, 1999In summary, FKBP-12 does not mediate the neurite outgrowth-promoting properties of neuroimmunophilin ligands (e.g., FK506). Instead, the neurotrophic properties of neuroimmunophilin ligands (FK506) and steroid hormones are mediated by disruption of steroid-receptor complexes.
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Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin
Journal of Molecular Biology, 1993Gregory D Van Duyne +2 more
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Cell, 1991Jun O Liu +2 more
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FKBP Binding Characteristics of Cardiac Microsomes from Diverse Vertebrates
Biochemical and Biophysical Research Communications, 2001Loice H Jeyakumar +2 more
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The human FK506-binding proteins: characterization of human FKBP19
Mammalian Genome, 2006Colin Robinson +2 more
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