Results 11 to 20 of about 4,458 (136)

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling. [PDF]

Glia
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Baldassarro VA, Brassart Q, Fraulob V, Calzà L, Krezel W.   +4 more
europepmc   +2 more sources

Biochemical Characterization of a Kunitz-Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis. [PDF]

Chem Biodivers
A Kunitz‐type serine protease inhibitor (JTI) purified from Mimosa regnellii seeds selectively targets melanoma cells. JTI triggers mitochondrial apoptosis, increases ROS and Ca2+ levels, arrests the cell cycle, and suppresses migration and angiogenesis without affecting healthy cells.
Rabêlo LMA, Cardoso PHO, Nobre LTDB, Dos Santos PIM, Lucena SV, Serquiz RP, Bemquerer MP, Rocha HAO, Nader HB, Dos Santos EA, de Oliveira AS, Frihling BEF, Migliolo L.   +12 more
europepmc   +2 more sources

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia [PDF]

J Neurosci Res
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Blaszczyk G, Weng C, Mohammadnia A, Cui Q, Giurleo A, Groh A, Plouffe C, Sirois J, Piscopo V, Yaqubi M, Taqvi A, Cassidy E, Martin L, Hall J, Dudley R, Srour M, Zandee S, Klement W, Larouche S, Prat A, Durcan T, Stratton J, Antel J, Moore G.   +23 more
europepmc   +2 more sources

Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder. [PDF]

Autism Res
ABSTRACT Mutations in the ATRX gene are a primary cause of alpha‐thalassemia intellectual disability X‐linked (ATRX) syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly.
Quesnel K, Ellegood J, Lerch JP, Bérubé NG.   +3 more
europepmc   +2 more sources

Refractive Index-Corrected Light-Sheet Microscopy for Macro-View Cardiovascular Imaging. [PDF]

Adv Sci (Weinh)
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Zhu E, Zhang Y, Zhao P, Cho JM, Wang Z, Li YR, Wang J, Margolis S, Wang S, Yang L, Chu A, Zhang Y, Gao L, Hsiai TK.   +13 more
europepmc   +2 more sources

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of survival of motor neuron (SMN) protein inducing progressive muscle weakness and atrophy due to motor neurons degeneration. Despite benefits of SMN restoration therapies in patients, motor defects are still persistent.
Bézier C, Cottin S, Hashemi PN, El Khoury M, Clerc Z, Balducci C, Sapaly D, Weill L, Lafont R, Veillet S, Dilda PJ, Charbonnier F, Latil M, Biondi O.   +13 more
europepmc   +2 more sources

Cabomba caroliniana and Schoenoplectus californicus as Antifouling Candidates: Anti‐Attachment and Toxicological Effects in Aurelia coerulea (Cnidaria, Scyphozoa)

Environmental Toxicology, Volume 41, Issue 6, Page 356-372, June 2026.
ABSTRACT Biofouling on artificial surfaces in aquatic ecosystems leads to significant economic losses. Current antifouling paints, while effective, often harm the aquatic environment. This study explores ecologically safe antifouling alternatives derived from plants, focusing on the aquatic macrophytes Cabomba caroliniana (CC) and Schoenoplectus ...
Mikael Luiz Pereira Morales, Laís Olivera das Neves, Ayman Shaik, Hafizah Chenia, Maximiliano Manuel Maronna, Sanye Soroldoni, Renato Mitsuo Nagata, Ng Haig They, Vanessa Ochi Agostini, Grasiela Lopes Leães Pinho   +9 more
wiley   +1 more source

Atenção integral à saúde da criança: odontologia [PDF]

, 2014
Este material tem como objetivo identificar possibilidades de realização de trabalho coletivo e interdisciplinar em saúde bucal com crianças, incluindo a promoção da saúde e a prevenção de doenças bucais na infância e reconhecendo as ações individuais no
Carcereri, Daniela Lemos, Delziovo, Carmem Regina, Döhms, Marcela Ceci, Faccin, Deniz, Lorenzzoni, Daniela, Miranda, Carla, Souza, Ana Izabel Jatobá de, Tognoli, Heitor   +7 more
core  

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL‐Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

Aging Cell, Volume 25, Issue 5, May 2026.
Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li, Jian Wu, Rui Liu, Qiang Li, Fei Xue   +4 more
wiley   +1 more source

Saúde da criança: odontologia [PDF]

, 2012
Este módulo apresenta ao especializando uma visão das atividades interdisciplinares envolvendo pactos, políticas e programas de saúde para a infância no Brasil e no mundo; a equipe de Saúde da Família e o planejamento de ações voltadas à Saúde da Criança,
Carcereri, Daniela Lemos, Döhms, Marcela, Faccin, Deniz, Lorenzzoni, Daniela, Miranda, Carla, Souza, Ana Izabel Jatobá de, Tognoli, Heitor   +6 more
core