Results 11 to 20 of about 2,646 (111)

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model. [PDF]

Glia
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Petrisko TJ, Chu SH, Gomez-Arboledas A, Zhang B, Tenner AJ.   +4 more
europepmc   +2 more sources

Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Preitner N, Dehlinger V, Rodriguez P, Fabbri K, Varisco Y, Pigni M, Lovison A, Münzenmaier L, Piorkowska K, Fuchs A, Ait-Bouziad N, Fournier N, Jepaul S, Molette J, Gabellieri E, Darmency V, Poli S, Pfeifer A, Kosco-Vilbois M, Capotosti F.   +19 more
europepmc   +2 more sources

Biochemical Characterization of a Kunitz-Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis. [PDF]

Chem Biodivers
A Kunitz‐type serine protease inhibitor (JTI) purified from Mimosa regnellii seeds selectively targets melanoma cells. JTI triggers mitochondrial apoptosis, increases ROS and Ca2+ levels, arrests the cell cycle, and suppresses migration and angiogenesis without affecting healthy cells.
Rabêlo LMA, Cardoso PHO, Nobre LTDB, Dos Santos PIM, Lucena SV, Serquiz RP, Bemquerer MP, Rocha HAO, Nader HB, Dos Santos EA, de Oliveira AS, Frihling BEF, Migliolo L.   +12 more
europepmc   +2 more sources

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia. [PDF]

J Neurosci Res
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Blaszczyk GJ, Weng C, Mohammadnia A, Cui QL, Giurleo A, Groh AMR, Plouffe C, Sirois J, Piscopo VEC, Yaqubi M, Taqvi A, Cassidy E, Martin LC, Hall JA, Dudley RWR, Srour M, Zandee SEJ, Klement W, Larouche S, Prat A, Durcan TM, Stratton JA, Antel JP, Moore GRW.   +23 more
europepmc   +2 more sources

Perfil do atendimento, conhecimento e atitudes acerca do pré-natal odontológico em Lagarto-SE [PDF]

, 2021
Introduction: Assistance to pregnant women in antenatal visit, in general, has not included oral health guidance, making it impossible to include those women in a full comprehensive health promotion proposal.
Neves, Charles dos Santos
core  

Avaliação da prescrição de suplementos de flúor pré-natal por ginecologistas-obstetras da cidade de Manaus-AM [PDF]

, 2010
O flúor tem sido utilizado como meio eficaz de prevenção e controle da doença cárie. Apesar do conhecimento comprovado de que sua ação preventiva em relação à doença cárie ocorre devido ao seu efeito local no período pós-eruptivo dos dentes, onde a sua ...
Caroline Saldanha Fernandez Alves
core   +1 more source

Association of Prodromal Parkinson's Disease‐Like Features in Long COVID With Dream‐Enactment Behaviours

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Emerging evidence links COVID‐19 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD‐like features remains unclear, particularly in long COVID participants with dream‐enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder.
Siyi Gong, Yaping Liu, Bei Huang, Ngan Yin Chan, Eemil Partinen, Christian Benedict, Bjørn Bjorvatn, Ilona Merikanto, Luigi De Gennaro, Yves Dauvilliers, Brigitte Holzinger, Juliana Yordanova, Maria Korman, Cátia Reis, Anne‐Marie Landtblom, Sergio Mota‐Rolim, Michael R. Nadorff, Frances Chung, Yuichi Inoue, Harald Hrubos‐Strøm, Kentaro Matsui, Courtney J. Bolstad, Pei Xue, Colin A. Espie, Charles M. Morin, Thomas Penzel, Giuseppe Plazzi, Markku Partinen, Yun Kwok Wing   +28 more
wiley   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Atenção odontológica na gestação: perfil de conhecimento de uma população de cirurgiões-dentistas [PDF]

, 2023
O período gestacional é uma fase fisiológica complexa, caracterizada por diversas mudanças físicas, psicológicas, hormonais e comportamentais que podem ter influência, direta ou indireta, na saúde bucal da gestante, podendo influenciar no risco de ...
Leal, Tauany Maria da Rocha Borges
core  

Predicting 7‐year‐olds mental health in the perinatal period: Development and internal validation of a multivariable model using the prospective ALSPAC cohort

JCPP Advances, Volume 6, Issue 3, September 2026.
Abstract Background Mental health difficulties in childhood are increasing. Prevention is the only sustainable and ethical public health approach. However, predicting which children are most at‐risk of mental health difficulties prior to symptoms emerging remains elusive.
Emma Butler, Michelle Spirtos, Linda M. O’Keeffe, Mary Clarke   +3 more
wiley   +1 more source