Results 31 to 40 of about 369,120 (314)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Applied SciencesReferees and assistant referees play a central role in enforcing the Laws of the Game during matches. The main referee holds ultimate responsibility, while assistant referees monitor offside situations, signal fouls outside the referee’s line of sight ...
Roni Gottlieb +4 more
doaj +1 more source
The Post-Communist Renegotiation of Slovenian National Symbols [PDF]
Družboslovne Razprave, 2017 This article explores how Slovenian collective memory and national identity have been renegotiated by post-communist political elites through the adoption of new state symbols in the light of changes connected to the collapse of communist ideology, the ...
Veronika Bajt
doaj
Singularity avoidance in quantum gravity
Physics Letters B, 2020 The purpose of this work is to investigate the consequences of quantum gravity for the singularity problem. We study the higher-derivative terms that invariably appear in any quantum field theoretical model of gravity, handling them both non ...
Iberê Kuntz, Roberto Casadio
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Wind Energy Harvesting with Vertically Aligned Piezoelectric Inverted Flags
Sensors, 2023 Wind-energy-harvesting generators based on inverted flag architecture are an attractive option to replace batteries in low-power wireless electronic devices and deploy-and-forget distributed sensors.
Kaidong Yang +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Worshipping with the U.S. Flag
ReligionsFor generations, a silent symbol of politics in U.S. religious congregations has been the presence of the national flag in worship spaces. Despite debates over the flag, there is limited empirical research on its contemporary prevalence or influence in ...
Steven Foertsch, Kevin D. Dougherty
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Revista de Derecho Político, 2018 Resumen: En este artículo se abordan dos elementos que han estado presentes en la conformación de nuestra identidad nacional: la bandera y la capitalidad.
Antonio Troncoso Reigada
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Journal of Symbolic Logic, 2007 AbstractAsymptotic extremal combinatorics deals with questions that in the language of model theory can be re-stated as follows. For finite models M, N of an universal theory without constants and function symbols (like graphs, digraphs or hypergraphs), let p(M, N) be the probability that a randomly chosen sub-model of N with ∣M∣ elements is isomorphic
openaire +3 more sources