Results 31 to 40 of about 326,913 (269)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Revista de Derecho Político, 2018 Resumen: En este artículo se abordan dos elementos que han estado presentes en la conformación de nuestra identidad nacional: la bandera y la capitalidad.
Antonio Troncoso Reigada
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Worshipping with the U.S. Flag
ReligionsFor generations, a silent symbol of politics in U.S. religious congregations has been the presence of the national flag in worship spaces. Despite debates over the flag, there is limited empirical research on its contemporary prevalence or influence in ...
Steven Foertsch, Kevin D. Dougherty
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ГОСУДАРСТВЕННЫЕ СИМВОЛЫ КАЛМЫКИИ В XX - НАЧАЛЕ XXI вв.: ИСТОРИЧЕСКИЕ И ПОЛИТИКО-ПРАВОВЫЕ АСПЕКТЫ
Oriental Studies, 2018 The article is devoted to the history of the state symbols of Kalmykia (the fl ag, the emblem and the anthem) from 1917 till the present days. Political and law aspects of the purpose of the regional state symbols are also considered.
Evgeniy Aleksandrovich Gunaev
doaj +1 more source
Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition.
PLoS ONE, 2021 A FLAG tag consisting of DYKDDDDK is an epitope tag that is frequently and widely used to detect recombinant proteins of interest. In this study, we performed a CRISPR-based genetic screening to identify factors involved in the detection of a FLAG-tagged
Xin-Yu Guo +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On Generalized Galois Cyclic Orbit Flag Codes
Mathematics, 2022 Flag codes that are orbits of a cyclic subgroup of the general linear group acting on flags of a vector space over a finite field, are called cyclic orbit flag codes.
Clementa Alonso-González +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source