Results 41 to 50 of about 369,120 (314)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
ГОСУДАРСТВЕННЫЕ СИМВОЛЫ КАЛМЫКИИ В XX - НАЧАЛЕ XXI вв.: ИСТОРИЧЕСКИЕ И ПОЛИТИКО-ПРАВОВЫЕ АСПЕКТЫ
Oriental Studies, 2018 The article is devoted to the history of the state symbols of Kalmykia (the fl ag, the emblem and the anthem) from 1917 till the present days. Political and law aspects of the purpose of the regional state symbols are also considered.
Evgeniy Aleksandrovich Gunaev
doaj +1 more source
Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition.
PLoS ONE, 2021 A FLAG tag consisting of DYKDDDDK is an epitope tag that is frequently and widely used to detect recombinant proteins of interest. In this study, we performed a CRISPR-based genetic screening to identify factors involved in the detection of a FLAG-tagged
Xin-Yu Guo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Aufgelöste historische Rechtsnormen und Gegenwart
Studia Historica Brunensia, 2015 This article describes the development of crests of cities and small towns with a particular focus on the crests of villages before 1990, when the municipal laws were published.
Ivan Štarha
doaj
On Generalized Galois Cyclic Orbit Flag Codes
Mathematics, 2022 Flag codes that are orbits of a cyclic subgroup of the general linear group acting on flags of a vector space over a finite field, are called cyclic orbit flag codes.
Clementa Alonso-González +1 more
doaj +1 more source
Journal of Combinatorial Theory, Series A, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Department of Mathematics, UMIST, P.O. Box 88, Manchester, M60 1QD, United Kingdom ( host institution ) +3 more
openaire +4 more sources
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source