Results 181 to 190 of about 147,336 (310)

1848-01-05 Kentucky Flag

open access: yes
Kentucky Flag published on January 5 ...
Kentucky Flag (Maysville, Ky.)
core  

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro   +7 more
wiley   +1 more source

SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin. [PDF]

open access: yesInt J Biol Sci
Wang X   +11 more
europepmc   +1 more source

1848-11-22 Kentucky Flag

open access: yes
Kentucky Flag published on November 22 ...
Kentucky Flag (Maysville, Ky.)
core  

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

open access: yesAdvanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei   +12 more
wiley   +1 more source

1848-07-14 Campaign Flag

open access: yes
Campaign Flag published on July 14 ...
Campaign Flag (Maysville, Ky.)
core  

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

open access: yesAdvanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu   +10 more
wiley   +1 more source

The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation. [PDF]

open access: yesMol Cell Proteomics
Zhu J   +7 more
europepmc   +1 more source

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