Results 101 to 110 of about 184,556 (342)

The IC2118 association: new T Tauri stars in high-latitude molecular clouds

, 2004
We identified new pre-main sequence stars in the region of high-latitude molecular clouds associated with the reflection nebula IC2118, around l = 208 degr and b = -27 degr. The stars were selected as T Tauri candidates in objective prism plates obtained
Alcalà, Alcalà, Alcalà, Aoyama, Bally, Baraffe, Bodenheimer, Brown, Brown, Cohen, Comerón, Gyulbudaghian, Hartigan, Hartmann, Kenyon, Kirkpatrick, Kun, Kun, Kun, L. E. B. Johansson, Luhman, M. Kun, Magnani, Martín, Martín, Meyer, Mizuno, N. A. Walton, Nakano, Ogura, Onishi, Palla, Penprase, Persi, Pickles, Preibisch, Rieke, S. Nikolić, Stanke, T. Prusti, White, Yonekura   +41 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Focal T2 and FLAIR hyperintensities within the infarcted area: A suitable marker for patient selection for treatment? [PDF]

PLoS ONE, 2017
Some authors use FLAIR imaging to select patients for stroke treatment. However, the effect of hyperintensity on FLAIR images on outcome and bleeding has been addressed in only few studies with conflicting results.466 patients with anterior circulation ...
Julia Meisterernst, Pascal P Klinger-Gratz, Lars Leidolt, Matthias F Lang, Gerhard Schroth, Pasquale Mordasini, Mirjam R Heldner, Marie-Luise Mono, Rebekka Kurmann, Monika Buehlmann, Urs Fischer, Marcel Arnold, Jan Gralla, Heinrich P Mattle, Marwan El-Koussy, Simon Jung   +15 more
doaj   +1 more source

Patient-Specific Fetal Dose Determination for Multi-Target Gamma Knife Radiosurgery: Computational Model and Case Report. [PDF]

, 2017
A 42-year-old woman at 29 weeks gestation via in vitro fertilization who presented with eight metastatic brain lesions received Gamma Knife stereotactic radiosurgery (GKSRS) at our institution. In this study, we report our clinical experience and a ...
Braunstein, Steve, Ma, Lijun, McDermott, Michael, Paulsson, Anna K, Phillips, Justin, Sneed, Patricia K, Theodosopoulos, Philip V   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

HeMIS: Hetero-Modal Image Segmentation

, 2016
We introduce a deep learning image segmentation framework that is extremely robust to missing imaging modalities. Instead of attempting to impute or synthesize missing data, the proposed approach learns, for each modality, an embedding of the input image
B Menze, G Tulder, I Goodfellow, L Zhao, M Hofmann, M Styner, N Guizard, NJ Tustison, S Buuren Van, S Hor, T Brosch   +10 more
core   +1 more source

Samuel Zyman’s "Concerto for Cello and Orchestra": An Analytical Approach [PDF]

, 2020
A professor at The Juilliard School since 1986, Zyman is one of Mexico’s foremost composers of today. His cello concerto (1990) exhibits solid technique, intense expression, and effective interaction between soloist and orchestra. The author demonstrates
Barrón Corvera, Jorge
core  

Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation [PDF]

, 2017
Magnetic Resonance Imaging (MRI) is widely used in routine clinical diagnosis and treatment. However, variations in MRI acquisition protocols result in different appearances of normal and diseased tissue in the images. Convolutional neural networks (CNNs)
Abolmaesumi, P., Descoteaux, M., Fedorov, A., Franz, A., Ghafoorian, M., Ginneken, B. van, Guttmann, C.R.G., Kapur, T., Karssemeijer, N., Leeuw, F.-E. de, Maier-Hein, L., Marchiori, E., Mehrtash, A., Pesteie, M., Platel, B., Tempany, C.M., Wells, W.M.   +16 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Meningeal contrast enhancement in multiple sclerosis: Assessment of field strength, acquisition delay, and clinical relevance.

PLoS ONE
Background/purposeLeptomeningeal enhancement (LME) on post-contrast FLAIR is described as a potential biomarker of meningeal inflammation in multiple sclerosis (MS).
Daniel M Harrison, Yohance M Allette, Yuxin Zeng, Amanda Cohen, Shishir Dahal, Seongjin Choi, Jiachen Zhuo, Jun Hua   +7 more
doaj   +1 more source