Results 131 to 140 of about 152,357 (314)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Long-term deformation of coastal volcanoes in SE-Asia: linking displacement rates, volcanic activity and flank instabilities. [PDF]

Bull Volcanol
Zorn EU, Amelung F, Massimetti F, Laiolo M, Coppola D, Walter TR, Lavallée Y, Darmawan H.   +7 more
europepmc   +1 more source

An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII

, 2017
Behnaz Pezeshkpoor, Ursula Schreck, Arijit Biswas, Julia Driesen, Ann‐Cristin Berkemeier, Anna Pavlova, Jens Müller, Johannes Oldenburg   +7 more
openalex   +2 more sources

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Evaluation of STONE, modified STONE, and CHOKAI scores for predicting ureteric stone disease in Indian emergency patients: A prospective observational study. [PDF]

Turk J Emerg Med
Manu M, Agrawal N, Mathew R, Pati SK, Mishra AK, Tripathy DK.   +5 more
europepmc   +1 more source

Both the 5S rRNA gene and the AT-rich flanks of xenopus laevis oocyte- type 5S rDNA repeat are required for histone H1-dependent repression of transcription of pol III-type genes in in vitro reconstituted chromatin [PDF]

, 1998
R Tomaszewski
openalex   +1 more source

Geomorphology of the SW flank of the Doña Juana Volcanic Complex, Colombia: interplay of fluvial, denudational, structural, and volcanic processes

, 2022
Susana Salazar, Ricardo Camacho, Santiago Villota, Natalia Pardo, Andrés Velásquez, Miguel Cabrera, Bernardo Pulgarín   +6 more
openalex   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Gold-incorporated hyaluronic acid nanoparticles enhance ablative radiotherapy efficacy in lung cancer. [PDF]

Int J Pharm X
Chen JL, Yang SJ, Lin LC, Pan CK, Tsai CY, Huang YS, Chen KC, Shieh MJ, Lin YL.   +8 more
europepmc   +1 more source

Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche. [PDF]

, 1998
Cailin Chen, Xun Li, Shankar M. Singh, Fernand Labrie   +3 more
openalex   +1 more source