RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang+7 more
wiley +1 more source
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu+17 more
wiley +1 more source
Optimal stenting duration following ureteroscopy and nephrolithotomy: systematic review and meta-analysis. [PDF]
Porto BC+5 more
europepmc +1 more source
A Unique THN Motif Is Critical for Enabling Efficient C‐Terminal Traceless Cleavage
THN is identified as the key motif to facilitate the rapid traceless cleavage of gp41‐1. The deflection of THN motif not only avoids the interaction between C‐exteins and active sites, but also separates Asp107 away from Asn125. In addition, a flexible block F contributes to faster C‐cleavage.
Ruocheng Gu+7 more
wiley +1 more source
Percutaneous pulsed radiofrequency treatment of the splanchnic nerves for chronic flank pain secondary to non-obstructive nephrolithiasis. [PDF]
Kim E, Banik RK.
europepmc +1 more source
Gene conversion of two functional goat alpha-globin genes preserves only minimal flanking sequences.
Eric A. Schon+2 more
openalex +1 more source
Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren+19 more
wiley +1 more source
Assessing the potential for in vivo modulation of <i>FTH1 gene</i> expression with small peptides to restore and enhance androgen receptor pathway inhibition in prostate cancer. [PDF]
Currie C+4 more
europepmc +1 more source