This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu +10 more
wiley +1 more source
An energy-efficient Flash-SAR ADC with two-step flash structure in a 0.18 μm CMOS process. [PDF]
Xue S.
europepmc +1 more source
Single‐Molecule Characterization of Bacterial Factor‐Dependent Transcription Activation by Rob
Factor‐dependent transcription activation is crucial and involves complex interactions between transcription factors, RNA polymerase, and promoter DNA. Using single‐molecule assays, we show that Rob prebinds RNAP to facilitate promoter search and enhances DNA unwinding and promoter escape.
Yuqiong Zhang +7 more
wiley +1 more source
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia +9 more
wiley +1 more source
Pacemaker Lead Endocarditis Secondary to Staphylococcus aureus Infection From a Flash Glucose Monitor Insertion Site in a Patient With Type 1 Diabetes: A Case Report. [PDF]
Linn K +3 more
europepmc +1 more source
Diagnostic accuracy of multimodal large language models in differentiating epileptic from functional seizures in smartphone recorded videos. [PDF]
Patel A +8 more
europepmc +1 more source
Quantitative Contrast-enhanced Ultrasound Evaluation of Hepatocellular Carcinoma Radioembolization. [PDF]
Wessner CE +14 more
europepmc +1 more source
A high-precision image-guided platform for studying spinal cord toxicity under ultra-high dose rate electron irradiation. [PDF]
Zhou B +9 more
europepmc +1 more source
Trends and Epidemiological Profile of Climate-Related Disasters in Spain between 1950 and 2024. [PDF]
Fernández García A +2 more
europepmc +1 more source

