Results 231 to 240 of about 456,109 (300)

Physical Unclonable Function Based on 3D-NAND Flash Array Structure With Multi-Chip Implementation. [PDF]

Small
Hwang H, Youn S, Park J, Yu D, Kim H.
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Prevalence and associated factors of depression, anxiety, and stress among flood-affected women in Bangladesh: a case study following 2024 flash flood. [PDF]

Front Public Health
Al Hattawi KS, Rahman MM, Alam E, Shobuj IA, Hossain MT.   +4 more
europepmc   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Musculoskeletal and Marrow Sparing With Proton FLASH Radiation Therapy in Juvenile Mice. [PDF]

Int J Radiat Oncol Biol Phys
Hu Z, Titt U, Li Y, Konradsson E, Aguilar EA, Neill DW, Connell L, Wang X, Meyer HJ, Gagea ML, McGovern SL, Schüler E, Mohan R.   +12 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

FLASH radiotherapy enables dose escalation resulting in improved survival in an orthotopic muscle-invasive bladder cancer mouse model. [PDF]

Br J Radiol
Ruan JL, Lee C, Sharma O, Lövgren N, Paillas S, Cooper C, Tullis IDC, Giaccia AJ, Kiltie AE, Petersson K.   +9 more
europepmc   +1 more source

Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection

Advanced Science, EarlyView.
Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendrišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal Otyepka   +11 more
wiley   +1 more source

Computational mechanisms of perception in autism revealed using games inspired by rodent operant tasks. [PDF]

Sci Adv
Chakravarty S, Do Q, Li Y, Torres-Lacarra V, Tager-Flusberg H, McGuire JT, Scott BB.   +6 more
europepmc   +1 more source

PP2A regulates shade avoidance response by dephosphorylating phytochrome-interacting factor 7 in Arabidopsis. [PDF]

Plant J
Cai X, Mitra O, Gustamante A, Tang W, Sun Y, Huq E.   +5 more
europepmc   +1 more source