Results 41 to 50 of about 261,611 (268)

Flash code: studying astrophysical thermonuclear flashes

Computing in Science & Engineering, 2000
The Center for Astrophysical Thermonuclear Flashes is constructing a new generation of codes designed to study runaway thermonuclear burning on the surface or in the interior of evolved compact stars. The center has completed the first version of Flash, Flash-1, which addresses various astrophysics problems.
Robert Rosner, Alan C. Calder, Jonathan Dursi, Bruce Fryxell, Donald Q. Lamb, Jens C. Niemeyer, Kevin Olson, Paul M. Ricker, Frank X. Timmes, James W. Truran, Henry M. Tufo, Yuan-Nan Young, Michael Zingale, Ewing L. Lusk, Rick Stevens   +14 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pengembangan Aplikasi Android Sebagai Media Pembelajaran Alat Transportasi

Jurnal Sarjana Teknik Informatika, 2020
Perkembangan teknologi memudahkan anak-anak untuk menerima berbagai infomasi. Salah satunya perangkat mobile yaitu smartphone Android. Smartphone dapat membantu dalam poses pembelajaran anak-anak. Seperti pengenalan alat transportasi.
Ardian Dwi Prasetyo
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Neutron dose evaluation in conventional and FLASH proton therapy

Brazilian Journal of Radiation Sciences, 2023
Cancer is the second leading cause of death for children and one of the treatment options for this disease is radiotherapy. Children treated with radiotherapy using photon beams are more likely to develop secondary neoplasms.
Felipe M .L. Souza, Ruy S. R. Neto, Arthur M. Rocha, S. C. Cardoso   +3 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Escribir con luz la mirada. Expresiones y metadiscursos de la fotografía-documento en el contexto contemporáneo español

Área Abierta, 2020
El presente artículo explora el uso de la luz en la fotografía no como un proceso técnico necesario, sino como un potente generador discursivo que escribe una mirada, un punto de vista sobre el mundo, al tiempo que reflexiona sobre el propio proceso ...
Marta Martín Núñez
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source