Results 31 to 40 of about 260,054 (268)

Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients

open access: yesFrontiers in Oncology, 2021
FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in
Elise Konradsson   +10 more
doaj   +1 more source

Flash code: studying astrophysical thermonuclear flashes

open access: yesComputing in Science & Engineering, 2000
The Center for Astrophysical Thermonuclear Flashes is constructing a new generation of codes designed to study runaway thermonuclear burning on the surface or in the interior of evolved compact stars. The center has completed the first version of Flash, Flash-1, which addresses various astrophysics problems.
Robert Rosner   +14 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

The ‘Green Flash.’ [PDF]

open access: yesNature, 1927
IF in my letter in NATURE of Dec. 3, I am understood to have suggested that the green flash seen at sunset had no cause other than a physiological one, I withdraw any implied or hinted suggestion in that direction; for it is evident that a great weight of authority is in favour of a physical cause. My letter, indeed, admitted the likelihood of greenish
openaire   +3 more sources

Foregrounding multivariate meanings in Nel Oliver’s video clip Upheaval: a multimodal discourse analysis advocating for the rights of unprivileged majorities

open access: yesCogent Arts & Humanities
This paper analyzes the meaning-encoding power of the compound channels used by the Beninese artist singer Noël Ahounou, best known as ‘Nel Oliver’ in his video clip titled Upheaval posted on https://www.youtube.com/watch?v=26WnI3l8QU8.
André Cocou Datondji   +2 more
doaj   +1 more source

A flash of magnesium [PDF]

open access: yesNature Chemistry, 2009
Magnesium is commonly found in rocks and sea water as well as living organisms. Paul Knochel relates how this element has also sparked a great deal of interest among chemists.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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