Results 111 to 120 of about 136,458 (320)

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Proposed treatment strategy for reactive hypoglycaemia

Frontiers in Endocrinology
Background/aimManaging reactive hypoglycaemia (RH) poses challenges due to limited and often ineffective treatment options. We report a case series and draw on this to propose a stepwise treatment approach consisting of lifestyle modifications, metformin,
Younes R. Younes, Nicholas Cron, Benjamin C.T. Field, Benjamin C.T. Field, Vidhu Nayyar, James Clark, Sunil Zachariah, Kavitha Lakshmipathy, Jimboy O. Isuga, Negar Maghsoodi, Julian Emmanuel   +10 more
doaj   +1 more source

Critical discrepancy in blood glucose control levels evaluated by glycated albumin and estimated hemoglobin A1c levels determined from a flash continuous glucose monitoring system in patients with type 2 diabetes on hemodialysis

Journal of Diabetes Investigation, 2020
We aimed to investigate if estimated hemoglobin A1c (eHbA1c) levels determined using a flash continuous glucose monitoring system could be an indicator of glycemic control status in hemodialysis patients with diabetes.
Emi Ushigome, Seiko Matsusaki, Nami Watanabe, Tetsuya Hashimoto, Naoto Nakamura, Michiaki Fukui   +5 more
doaj   +1 more source

Effect of switch from flash glucose monitoring to flash glucose monitoring with real-time alarms on hypoglycaemia in people with type 1 diabetes mellitus.

Primary Care Diabetes
We aimed to evaluate the utility of the FreeStyle Libre 2 device for reducing time below range level 1 and level 2 compared with the Freestyle Libre device (without alarms) in people with type 1 diabetes mellitus.
A. Gutiérrez-Pastor, J. Quesada, MM Soler-Martínez, C. Carratalá Munuera, FJ Pomares-Gómez   +4 more
semanticscholar   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Effects of unrestricted access to flash glucose monitoring in type 1 diabetes

Endocrinology, Diabetes & Metabolism, 2020
Aims We assessed adherence and long‐term effects on HbA1c of unrestricted access to flash glucose monitoring (FGM) in a single diabetes centre. Methods In this observational study, we reviewed data files for all 411 patients with type 1 diabetes ...
Klavs Würgler Hansen
doaj   +1 more source

NFC2BLE Communications’ Bridge: From Flash to Continuous Monitoring of Biological Parameters

Elektronika ir Elektrotechnika, 2020
The devices for monitoring biological variables have become a hot topic in the last years. An important aspect in the design of these wearable devices is the continuous communication, as well as the associated energy consumption. As a result, the concept
Jose Maria Vicente, Ernesto Avila-Navarro, Alberto Rodriguez-Martinez, Miguel Angel de la Casa Lillo, Jose Maria Sabater-Navarro   +4 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Policy-based management for body-sensor networks [PDF]

, 2007
Accepted ...
Dulay, N, Heeps, S, Katsiri, E, Keoh, SL, Lupu, E, Pryce, N, Schaeffer, AE, Sloman, M, Strowes, S, Sventek, J, Twidle, K   +10 more
core  

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source