Results 51 to 60 of about 645,669 (304)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluating Fuel Properties of Strained Polycycloalkanes for High-Performance Sustainable Aviation Fuels

Energies
Sustainable aviation fuel (SAF) is a drop-in alternative to conventional jet fuels, designed to reduce greenhouse gas (GHG) emissions while requiring minimal infrastructure changes and certification under the American Society for Testing and Materials ...
Dilip Rijal, Vladislav Vasilyev, Yunxia Yang, Feng Wang   +3 more
doaj   +1 more source

Experimental thermal hazard investigation on carbonate electrolytes using a cone calorimeter

Case Studies in Thermal Engineering, 2021
During the thermal runaway (TR) processing of lithium-ion batteries (LIBs), electrolyte would release most of the heat as the main component. Thus, study on the fire risk of electrolyte is conductive to quantitatively evaluate the safety of LIBs. In this
Que Huang, Song Lu, Xiaozhao Liu, Kaihui Zheng, Dengji Xu, Changcheng Liu   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Sensitivity Analysis of Flash Flood Hazard on Sediment Load Characteristics

Frontiers in Earth Science, 2021
Changing climate has raised attention toward weather-driven natural hazards, such as rain-induced flash floods. The flooding model is an efficient tool used in flash flood warning and hazard management.
Hongxi Liu, Hongxi Liu, Yujun Yi, Zhongwu Jin   +3 more
doaj   +1 more source

Analysis of Moon impact flashes detected during the 2012 and 2013 Perseids [PDF]

, 2015
We present the results of our Moon impact flashes detection campaigns performed around the maximum activity period of the Perseid meteor shower in 2012 and 2013.
Ana-Hernández, Leonor, Cabrera-Caño, Jesús, Fonseca, Fernando, Madiedo, José M., Morales, Nicolás, Organero, Faustino, Ortiz, José L.   +6 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Properties of waste-distilled engine oil and biodiesel ternary blends

Heliyon, 2021
This study aims to improve the fuel properties limitations of biodiesel which affect the engine performance characteristics in diesel engines. A ternary mixture simplex axial design model was used to determine the fuel properties of ternary blend mixture
Dennis Kipkorir, Francis Nturanabo, Robert Tewo, Hilary Rutto, Christopher Enweremadu   +4 more
doaj   +1 more source

STUDI KOMPARASI ANTARA PENGGUNAAN MEDIA PEMBELAJARAN MACROMEDIA FLASH DAN POWER POINTSERTA PENGARUHNYA TERHADAP HASIL BELAJAR SOSIOLOGI SISWA KELAS XI IPS SMA NEGERI 3 SURAKARTA TAHUN PELAJARAN 2015/2016 [PDF]

, 2016
Penilitian ini bertujuan untuk mengetahui: (1) Perbedaan penggunaan media pembelajaran Macromedia Flash dan Power Point terhadap hasil belajar sosiologi siswa(2) Pengaruh penggunaan media pembelajaran Macromedia Flash dan Power Point terhadap hasil ...
TIA F., GALUH
core  

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source