Results 101 to 110 of about 69,857 (316)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Solar photochemical process engineering for production of fuels and chemicals [PDF]
The engineering costs and performance of a nominal 25,000 scmd (883,000 scfd) photochemical plant to produce dihydrogen from water were studied. Two systems were considered, one based on flat-plate collector/reactors and the other on linear parabolic ...
Biddle, J. R. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
International Journal of Bio-Resource and Stress Management, 2021 This research investigation was undertaken in ANDUAT, Kumarganj, Ayodhya, Uttar Pradesh, India to study the numerical optimization of natural convection heat suppression in a solar flat plate collector with straight fins.
A. D. Gupta +4 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Experimental comparison of serpentine and parallel-tubes flat plate collectors for different flow rates [PDF]
, 2019 Comparación experimental del comportamiento térmico de dos captadores solares térmicos, uno serpentín y otro parrilla. In the paper, two flat plate solar collectors were simultaneously tested in a side-by-side facility at the UMA, following the steady ...
Cejudo-Lopez, Jose Manuel +1 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
EAI Endorsed Transactions on Energy WebSmall sized absorber in a flat plate solar collector is beneficial in terms of cost and minimum heat losses. However, its detailed thermal performance compared to standard size collector is still not fully understood.
Kumar Aditya Chandra +3 more
doaj +1 more source
Thermal performance evaluation of MSFC hot air collectors with various flow channel depth [PDF]
The test procedures used and the results obtained during the evaluation test program on the MSFC air collector with flow channel depth of 3 in., 2 in., and 1 in., under simulated conditions are presented.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source