Results 81 to 90 of about 1,186,204 (302)

The Efficiency of New Solar Flat-Plate Collector

open access: yes, 2011
Aerogel is a highly porous material. It has the best thermal insulation properties in all solid-state materials. This paper carried out a preliminary study to see the influence on efficiency of flat-plate collector used aerogel.
Rui Duan
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Exergy analysis of a flat plate solar collector

open access: yesJournal of Energy in Southern Africa, 2017
In this study, exergetic performance analysis of flat plate solar collector has been carried out analytically. A comprehensive mathematical modelling of thermal performance is simulated using MATLAB simulink and optimal geometrical and thermodynamic ...
Sunil Chamoli
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

External heating of a flat plate in a convective flow [PDF]

open access: yes, 1984
The steady-state and íransient processes of the exteinal heating of a flat píate under a convective flow is studied in thís paper, with inclusión of the axial heat conduction tíirough the píate.
Treviño, César   +1 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Heat Transfer by Nanofluids Through a Flat Plate Solar Collector [PDF]

open access: yes, 2014
Forced convective flow and heat transfer by different nanofluids through a flat plate solar collector is analyzed numerically by this article. The solar collector has the flat-plate cover and sinusoidal wavy absorber. Four different nanofluids like water-
Alim, M.A.   +2 more
core   +1 more source

CFD Simulation of Enhancement Techniques in Flat Plate Solar Water Collectors

open access: yesمجلة النهرين للعلوم الهندسية, 2017
The present work is a numerical study of thermal performance of modified flat plate solar water collectors. Numerical simulations have been done by solving the governing equations (Continuity, Momentum and Energy) equations in the laminar regime , three ...
Jafar Mehdi Hassan   +2 more
doaj  

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