Results 61 to 70 of about 1,186,204 (302)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Flat plate collector with bifacially irradiated absorber
, 2022 S.62-65A new flat plate collector has been developed which, especially during times of low radiation conditions, reaches higher efficiencies than any other collector known so far. The absorber plate is insulated with Transparent Insulation Material (TIM)
Rommel, M. +3 more
core +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Serpentine Flat Plate Collector Thermal Performance Testing
, 2011 Due to the conventional flat plate solar collector has low efficient, it is necessary to make some improvements in the structure of conventional flat solar collector. This research improved the structure of conventional flat solar collector and conducted
Hua Wang +3 more
core +1 more source
A review of solar collectors and thermal energy storage in solar thermal applications [PDF]
, 2013 Thermal applications are drawing increasing attention in the solar energy research field, due to their high performance in energy storage density and energy conversion efficiency. In these applications, solar collectors and thermal energy storage systems
Zhao, Changying +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Designing photovolaic/thermal solar collectors for building integration [PDF]
, 2008 With concern growing over the environment and resource use, there has been greater emphasis placed on sustainability, particularly in the built environment.
Carson, James K. +2 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Statistical analysis of factors affecting the flow characteristics and thermal efficiency of a building integrated thermal (bit) solar collector [PDF]
, 2014 Previous research has identified four factors (array geometry, manifold to riser channel ratio, flow direction in manifold, and the mass flow rate) which will influence the distribution of internal fluid flow within a solar thermal collector.
Ghani, Faisal Abid, Duke, Mike
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source