Results 51 to 60 of about 69,857 (316)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Techno-economic analysis of hybrid solar thermal systems with flat plate and parabolic trough collectors in industrial applications

open access: yesAlexandria Engineering Journal
Hybrid configurations that combine two different solar thermal collector technologies are considered to improve the economic competitiveness of solar systems in district heating applications.
Josué F. Rosales-Pérez   +4 more
doaj   +1 more source

The Comparison of Solar Energy Gaining Effectiveness between Flat Plate Collectors and Evacuated Tube Collectors with Heat Pipe: Case Study

open access: yesEnergies, 2020
In Poland, various solar collector systems are used; among them, the most popular are flat plate collectors (FPCs) and evacuated tube collectors (ETCs). The work presents two installations located at a distance of 80 km apart, working in similar external
Piotr Olczak   +2 more
doaj   +1 more source

Experimental Analysis of a Flat Plate Solar Collector with Integrated Latent Heat Thermal Storage [PDF]

open access: yes, 2017
In the present paper, an experimental analysis of a solar water heating collector with an integrated latent heat storage unit is presented. With the purpose to determine the performance of a device on a lab scale, but with commercial features, a flat ...
Carmona, M. (Mauricio)   +2 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Performance Evaluation of a Solar Dryer with Finny, Perforated Absorber Plate Collector Equipped with an Air Temperature Control System for Dill Drying

open access: yesJournal of Agricultural Machinery, 2015
Dill is one of the most important plants in the world because of its medicinal properties and it is widely used as a vegetable in the most parts of Iran.
M Razmipour   +3 more
doaj   +1 more source

Relative potentials of concentrating and two-axis tracking flat-plate photovoltaic arrays for central-station applications [PDF]

open access: yes
The purpose of this study is to assess the relative economic potentials of concenrating and two-axis tracking flat-plate photovoltaic arrays for central-station applications in the mid-1990's.
Borden, C. S., Schwartz, D. L.
core   +1 more source

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