Results 121 to 130 of about 462,633 (304)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Solar hot water system installed at Day's Inn Motel, Dallas, Texas (Valley View) [PDF]

The solar system was designed to provide 65 percent of the total domestic hot water (DHW) demand. A liquid (water) flat plate collector (1,000 square feet) system automatically drains into the 1,000 gallon steel storage tank when the solar pump is not ...

core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Impact of space-time curvature coupling on the vacuum energy induced by a magnetic topological defect in flat space-time of arbitrary dimension

Nuclear Physics B
We have investigated vacuum polarization of a quantized charged massive scalar field in the presence of a magnetic topological defect, modeled as an impenetrable tube of finite thickness carrying magnetic flux. At the tube’s surface, we imposed a general
V.M. Gorkavenko, O.V. Barabash, I.V. Ivanchenko, P.O. Nakaznyi, M.S. Tsarenkova, N.S. Yakovenko, A.O. Zaporozhchenko   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Solar hot water system installed at Days Inn Motel, Jacksonville, Florida [PDF]

The solar system was designed to provide 65 percent of the hot water demand. Water in the liquid flat plate collector (900 square feet) system automatically drains into the 1000 gallon lined and vented steel storage tank when the pump is not running ...

core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Filled Function with Single Parameter Application on Minimum Pumping Power Air Flow Over Staggered Adiabatic Flat Tubes

Tikrit Journal of Engineering Sciences
An engineering application of a filled function with a single parameter that has been optimized for a minimum of pumping in flow over two row staggered flat tubes, the minimum of pumping power in air flow are investigated in current study based on the ...
Mohammed I. A. Tahseen, Qasim Nasir Husain, Shehab Ahmed Ibrahem, Tahseen Ahmad Tahseen, M. Ishak, M. M. Rahman   +5 more
doaj   +1 more source

Study on the Pressure Bearing Capability of Folded Multi-Port Flat Tube. [PDF]

Materials (Basel), 2019
Tang D, Chen X, Zhao L, Zou T, Wang H, Li D, Peng Y, Wu P.   +7 more
europepmc   +1 more source