Results 51 to 60 of about 29,270 (312)

Arguments against the flatness problem [PDF]

, 2022
editorial reviewedSeveral authors (including myself) have made claims, none of which has been convincingly rebutted, that the flatness problem, as formulated by Dicke and Peebles, is not really a problem but rather a misunderstanding.
Helbig, Phillip
core   +1 more source

Flatness-based trajectory generator for VTOL transition aircraft [PDF]

, 2020
LAUREA MAGISTRALELa ricerca e lo sviluppo di velivoli a pilotaggio remoto con configurazione a decollo e atterraggio verticale e transizione è uno degli ultimi obiettivi nel campo aeronautico. Velivoli che decollano e atterrano verticalmente o volano a
Capodiferro, Marco, Castelli Dezza, Giovanni   +1 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

FAM Relative Flatness Aware Minimization

, 2023
Flatness of the loss curve around a model at hand has been shown to empirically correlate with its generalization ability. Optimizing for flatness has been proposed as early as 1994 by Hochreiter and Schmidthuber, and was followed by more recent ...
Kleesiek, Jens,, Abourayya, Amr,, Petzka, Henning,, Adilova, Linara,, Dada, Amin,, Egger, Jan,, Kamp, Michael,, Lund University., Li, Jianning,   +8 more
core   +1 more source

Riccati PDEs That Imply Curvature-Flatness

, 2021
In this paper the following three goals are addressed. The first goal is to study some strong partial differential equations (PDEs) that imply curvature-flatness, in the cases of both symmetric and non-symmetric connection.
Iulia Hirica, Gabriel Pripoae, Constantin Udriste, Ionel Tevy   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Measuring nonstabilizerness via multifractal flatness [PDF]

, 2023
Universal quantum computing requires nonstabilizer (magic) quantum states. Quantifying the nonstabilizerness and relating it to other quantum resources is vital for characterizing the complexity of quantum many-body systems. In this work, we prove that a
Schirò, Marco, Sierant, Piotr, Turkeshi, Xhek   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

RECYCLING RECOVERED WOOD-BASED MATERIALS. FLATNESS, MOR AND MOE OF PANELS MADE FROM RECOVERED WOODEN BASED MATERIALS [PDF]

Pro Ligno, 2015
The objective of the research was to study the mechanical properties of recovered solid wood and wood-based materials, to create new panels made of strips of recovered oak and spruce wood, particleboards and blockboards and to study their mechanical ...
Andrea DEÁK, Marina CIONCA, Mihaela POROJAN, Alin M. OLĂRESCU   +3 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source