Results 71 to 80 of about 29,270 (312)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Vertical Deformation Mapping: Steering Optimiser Toward Flat Minima

open access: yesCAAI Transactions on Intelligence Technology
Standard deep learning optimisation is typically conducted on shape‐fixed loss surfaces. However, shape‐fixed loss surfaces may impede optimisers from reaching flat regions closely associated with strong generalisation.
Liangming Chen   +4 more
doaj   +1 more source

Flatness of the Kiva network.

open access: yes, 2018
Flatness is defined as the fraction of unbiased country–pairs (|z| ≤ 2) under the null model. The flatness is measured by comparing the observed flow with the expected flow as described in the text.
Boleslaw Szymanski (756101)   +7 more
core   +1 more source

Zariski rings and flatness of completion [PDF]

open access: yes, 1991
We relate flatness and faithful flatness of the completion to the comparison and Zariskian property resp. of the filtration.
Van Oystaeyen, F.   +2 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

The Flatness and Other Landscapes [PDF]

open access: yes, 2001
Review of: The Flatness and Other Landscapes.
Price, John
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Flatness and fusion coefficients [PDF]

open access: yes, 2001
This paper addresses the problem of how to directly read off the 'fusion coefficients' (for the tensor-products of bimodules arising in the 'tower of the basic construction) for a subfactor, from the data of the associated paragroup. The solution to this
Kodiyalam, Vijay, Sunder, V. S.
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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