Results 171 to 180 of about 68,853 (304)

Histopathological Alterations and Dysregulation of Type I Interferon Signaling in the Human Cerebral Cortex During Severe Dengue

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Dengue virus (DENV) is a major arthropod‐borne pathogen, endemic in over 100 countries and posing global health challenges. While innate immune responses and viral evasion mechanisms have been extensively studied in animal models and mononuclear cells, severe dengue can affect multiple tissues, including the central nervous system (CNS ...
Leandro Mantovani de Castro, Elaine Raniero Fernandes, Juarez Antonio Simoes Quaresma, Carmen Lucia Penteado Lancelotti, Maria Irma Seixas Duarte, Leda Viegas de Carvalho, Ricardo Penny, Pedro Fernando da Costa Vasconcelos, Evandro Sobroza de Mello, Mirian Nacagami Sotto, Carla Pagliari   +10 more
wiley   +1 more source

Advances in Alphavirus and Flavivirus Research

Viruses
Newly emerging viruses, primarily zoonotic or vector-borne, pose a persistent threat to public health and have led to outbreaks of global concern [...]
Kim, YC, Reyes-Sandoval, A
openaire   +4 more sources

Are we prepared for emerging flaviviruses in Europe? Challenges for vaccination

Human Vaccines & Immunotherapeutics, 2018
Tick-borne encephalitis and West Nile fever are endemic flavivirus diseases in Europe. Climate change, virus evolution, and social factors may increase the risk of these flavivirus infections and may lead to the emergence of other flaviviruses in Europe ...
Patricia Kaaijk, Willem Luytjes
doaj   +1 more source

Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites.

PLoS ONE
Flaviviruses are a diverse group of RNA viruses known for their significant impact on human health worldwide. We generated a series of reporters that included cleavage sequences from the dengue virus type 2 polyprotein and co-transfected with plasmids ...
Alexius O Dingle, Zach N Adelman
doaj   +1 more source

Establishment and Characterization of Japanese Encephalitis Virus-Specific, Human CD4 ⁺ T-Cell Clones: Flavivirus Cross-Reactivity, Protein Recognition, and Cytotoxic Activity [PDF]

, 1998
Hirokuni Aihara, Tomohiko Takasaki, Takaji Matsutani, Ryuji Suzuki, Ichiro Kurane   +4 more
openalex   +1 more source

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

Nature Communications, 2018
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally ...
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft   +8 more
doaj   +1 more source

Molecular Determinants of Flavivirus Virion Assembly.

TIBS -Trends in Biochemical Sciences. Regular ed, 2021
Trisha R. Barnard, Quinn H. Abram, Q. Lin, Alex B. Wang, S. Sagan   +4 more
semanticscholar   +1 more source

TRIMming down Flavivirus Infections

Viruses
Flaviviruses comprise a large number of arthropod-borne viruses, some of which are associated with life-threatening diseases. Flavivirus infections are rising worldwide, mainly due to the proliferation and geographical expansion of their vectors. The main human pathogens are mosquito-borne flaviviruses, including dengue virus, Zika virus, and West Nile
Marion Cannac, Sébastien Nisole
openaire   +3 more sources

cis - and trans -Acting Elements in Flavivirus RNA Replication [PDF]

, 2000
Alexander A. Khromykh, Petra L. Sedlak, Edwin G. Westaway   +2 more
openalex   +1 more source

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core