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Shaping the flavivirus replication complex: It is curvaceous!
Cellular Microbiology, 2018 Flavivirus replication is intimately involved with remodelled membrane organelles that are compartmentalised for different functions during their life cycle. Recent advances in lipid analyses and gene depletion have identified a number of host components
Turgut E Aktepe, Jason M Mackenzie
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ACS Infectious Diseases, 2015
Many flaviviruses are significant human pathogens that are transmitted by mosquitoes and ticks. Although effective vaccines are available for yellow fever virus, Japanese encephalitic virus, and tick-borne encephalitis virus, these and other flaviviruses still cause thousands of human deaths and millions of illnesses each year.
Qing-Yin, Wang, Pei-Yong, Shi
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Many flaviviruses are significant human pathogens that are transmitted by mosquitoes and ticks. Although effective vaccines are available for yellow fever virus, Japanese encephalitic virus, and tick-borne encephalitis virus, these and other flaviviruses still cause thousands of human deaths and millions of illnesses each year.
Qing-Yin, Wang, Pei-Yong, Shi
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Platelets in the pathogenesis of flavivirus disease
Current Opinion in Virology, 2022Research on the role of platelets in modulating innate and adaptive host immune responses has gaining importance in the last two decades. Since the virus can directly interact with platelet receptors and modulate the host immune response, understanding the role of platelets in viral pathogenesis would pave way for novel therapeutic means.
Agiesh Kumar Balakrishna Pillai +3 more
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Microscopy techniques in flavivirus research
Micron, 2014The Flavivirus genus is composed of many medically important viruses that cause high morbidity and mortality, which include Dengue and West Nile viruses. Various molecular and biochemical techniques have been developed in the endeavour to study flaviviruses.
Mun Keat Chong +4 more
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Recombination and flavivirus vaccines: a commentary
Vaccine, 2005A review article recently appeared in the Lancet by Seligman and Gould, in which the authors raise a safety concern for flavivirus vaccines based on possible recombination between wild-type viruses and live, attenuated vaccine viruses. Flaviviruses are small enveloped viruses with a single positive sense RNA genome containing a single long open reading
Monath, Thomas P. +16 more
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Flavivirus Replication Strategy
1987Publisher Summary The family Flaviviridae comprises 65 species, which globally represent the most widespread and medically important of the arthropod-borne viruses. Knowledge of flavivirus replication strategy has accumulated slowly—current information indicates that the strategy is apparently simple, involving the genome as the single capped ...
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Zika virus: An emerging flavivirus
Journal of Microbiology, 2017Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific ...
Sang-Im, Yun, Young-Min, Lee
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A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness
Cell, 2022Yibin Zhu, Ziwen Liu, Liangqin Tong
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Establishment and Application of Flavivirus Replicons
2018Dengue virus (DENV) and Zika virus (ZIKV) are enveloped, positive-strand RNA viruses belonging to the genus Flavivirus in the family Flaviviridae. The genome of ~11 kb length encodes one long open reading frame flanked by a 5' and a 3' untranslated region (UTR). The 5' end is capped and the 3' end lacks a poly(A) tail. The encoded single polyprotein is
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