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2021
A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
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A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
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Unraveling a Flavivirus Enigma
Science, 2014The structure of a flavirirus nonstructural protein provides mechanistic understanding for many of its functions. [Also see Report by Akey et al. ]
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Flavivirus Structure and Membrane Fusion
2003Publisher Summary Flaviviruses are spherical enveloped viruses with a diameter of approximately 50 nm that contain only three structural proteins: E (envelope), prM/M (membrane), and C (capsid). This chapter focuses primarily on structural aspects of the envelope glycoproteins, their organization in the viral envelope, and the mechanism of virus ...
Steven L. Allison, Franz X. Heinz
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Establishment and Application of Flavivirus Replicons
2018Dengue virus (DENV) and Zika virus (ZIKV) are enveloped, positive-strand RNA viruses belonging to the genus Flavivirus in the family Flaviviridae. The genome of ~11 kb length encodes one long open reading frame flanked by a 5' and a 3' untranslated region (UTR). The 5' end is capped and the 3' end lacks a poly(A) tail. The encoded single polyprotein is
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Targeting the Flavivirus Helicase
Antiviral Research, 2011Eloise Mastrangelo +7 more
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