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Flavivirus Replication Strategy
1987Publisher Summary The family Flaviviridae comprises 65 species, which globally represent the most widespread and medically important of the arthropod-borne viruses. Knowledge of flavivirus replication strategy has accumulated slowly—current information indicates that the strategy is apparently simple, involving the genome as the single capped ...
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Zika virus: An emerging flavivirus
Journal of Microbiology, 2017Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific ...
Sang-Im Yun, Young-Min Lee
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2021
A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
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A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
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Flavivirus Structure and Membrane Fusion
2003Publisher Summary Flaviviruses are spherical enveloped viruses with a diameter of approximately 50 nm that contain only three structural proteins: E (envelope), prM/M (membrane), and C (capsid). This chapter focuses primarily on structural aspects of the envelope glycoproteins, their organization in the viral envelope, and the mechanism of virus ...
Steven L. Allison, Franz X. Heinz
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Unraveling a Flavivirus Enigma
Science, 2014The structure of a flavirirus nonstructural protein provides mechanistic understanding for many of its functions. [Also see Report by Akey et al. ]
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Establishment and Application of Flavivirus Replicons
2018Dengue virus (DENV) and Zika virus (ZIKV) are enveloped, positive-strand RNA viruses belonging to the genus Flavivirus in the family Flaviviridae. The genome of ~11 kb length encodes one long open reading frame flanked by a 5' and a 3' untranslated region (UTR). The 5' end is capped and the 3' end lacks a poly(A) tail. The encoded single polyprotein is
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Targeting the Flavivirus Helicase
Antiviral Research, 2011Eloise Mastrangelo +7 more
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