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Flaviviruses and flavivirus vaccines
Vaccine, 2012Several human-pathogenic flaviviruses (including yellow fever, dengue, Japanese encephalitis, West Nile and tick-borne encephalitis viruses) have a significant public health impact in different parts of the world and the potential of emerging in previously non-endemic regions.
Franz X, Heinz, Karin, Stiasny
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Protein Evolution in the Flaviviruses
Journal of Molecular Evolution, 2020Proteins are commonly used as molecular targets against pathogens such as viruses and bacteria. However, pathogens can evolve rapidly permitting their populations to increase in protein diversity over time and thus escape to the activity of a molecular therapy.
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Hepatopathology of flaviviruses
Journal of Hepatology, 2022Adam L. Bailey, Michael S. Diamond
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Immune Modulation by Flaviviruses
2003Flaviviruses cause pleomorphic disease with significant morbidity and mortality worldwide. Interestingly, in contrast to most viruses, which subvert or avoid host immune systems, members of the neurotropic Japanese encephalitis serocomplex cause functional changes associated with increased efficacy of the immune response. These viruses induce increased
Nicholas J, King +2 more
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Flaviviruses and Apoptosis Regulation
2004The flaviviruses comprise a large genus of medically important arthropod-transmitted, enveloped viruses. Flaviviruses cause a variety of human diseases ranging from mild febrile illnesses to severe hemorrhagic manifestations (yellow fever [YF], dengue [DEN]; Monath 2001; Guzman and Kouri 2002) or meningo-encephalitic syndromes (Japanese encephalitis ...
A, Catteau, M P, Courageot, P, Desprès
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The entry machinery of flaviviruses
2004We have been using the flavivirus tick-borne encephalitis virus (TBEV) as a model system for investigating the molecular mechanisms underlying the membrane fusion process mediated by a class II viral fusion protein, the flavivirus envelope protein E.
F X, Heinz, K, Stiasny, S L, Allison
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Genetic resistance to flaviviruses
2003Resistance to flavivirus-induced disease in mice was first discovered in the 1920s and was subsequently shown to be controlled by the resistant allele of a single dominant autosomal gene. While the majority of current laboratory mouse stains have a homozygous-susceptible phenotype, the resistant allele has been found to segregate in wild mouse ...
Margo A, Brinton, Andrey A, Perelygin
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Molecular biology of flaviviruses
2003Publisher Summary This chapter summarizes the current understanding of the molecular biology of flaviviruses and points out promising avenues for future work. The molecular biology of flaviviruses is best understood in the context of the viral life cycle, which provides a framework for the organization of this chapter.
Brett D, Lindenbach, Charles M, Rice
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Flaviviruses and Kidney Diseases
Advances in Chronic Kidney Disease, 2019The genus Flavivirus comprises approximately 73 viruses, which share several common aspects, such as dimension, structure, nucleic acid properties, and shape in electronic microscopy. Global incidence of flavivirus infection increased dramatically over the last decades, causing large outbreaks in several areas of the world.
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