Results 101 to 110 of about 35,991 (298)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Tough challenges for testing Ebola therapeutics
Bulletin of the World Health Organization, 2015 Therapies for Ebola virus disease are urgently needed, but they must be rigorously tested for safety and efficacy before any mass roll-out to patients. Fiona Fleck reports.
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Revista Brasileira de Pesquisa em Educação em Ciências, 2011 Neste artigo sinalizamos possibilidades para a promoção do desenvolvimento profissional dos formadores de professores de Química, de modo que sua ação docente possa favorecer uma formação inicial de professores em consonância com as discussões ...
Fábio Peres Gonçalves +2 more
doaj
, 1997 Recension av Ludwik Fleck, Uppkomsten och utvecklingen av ett vetenskapligt ...
Billing, Björn,
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Thailand?s health ambitions pay off
Bulletin of the World Health Organization, 2014 With political will and public health vision, Thailand is making essential health services available to all its citizens free of charge. Suwit Wibulpolprasert talks to Fiona Fleck.
doaj +1 more source
Brief von Kurt Rothschild an Christian Fleck
BRIEF VON KURT ROTHSCHILD AN CHRISTIAN FLECK Brief von Kurt Rothschild an Christian Fleck ([1]
Rothschild, Kurt W.
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Rapid Ebola tests hold promise
Bulletin of the World Health Organization, 2015 New rapid diagnostic tests for Ebola may help Guinea, Liberia and Sierra Leone reach zero cases and allow routine health services to resume. Fiona Fleck reports.
doaj +1 more source