Results 81 to 90 of about 33,295 (296)
Most people can stay fit and healthy into old age
Bulletin of the World Health Organization, 2014 Bruno Vellas tells Fiona Fleck why governments must act now to help older people stay fit and healthy.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A epistemologia de Ludwick Fleck: subsídios para a prática interdisciplinar em saúde
Texto & Contexto Enfermagem, 2005 Este artículo tiene como objetivo presentar una síntesis del pensamiento de Ludwick Fleck con la finalidad de contribuir para la reflexión sobre la interdisciplinariedad en el área de la salud.Inicialmente, se presenta la teoría de Fleck al respecto de ...
Eliane Matos +2 more
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Filosofia e História da BiologiaEste artigo aborda a carreira, interesses profissionais e o contexto sócio-político em que viveu Ludwik Fleck A seguir, foca nos conceitos de “estilo de pensamento” e “coletivo de pensamento” que fazem parte de sua epistemologia.
Marllon Rosa +1 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Countries vindicate cautious stance on e-cigarettes
Bulletin of the World Health Organization, 2014 Countries signed up to an international tobacco control treaty have embraced controversial WHO proposals to regulate electronic cigarettes. Armando Peruga tells Fiona Fleck why.
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