Results 81 to 90 of about 35,991 (298)
, 2009 Michigan State University Distinguished Professor Leonard M. Fleck discusses issues raised in his recent book, "Just caring : health care rationing and democratic deliberation".
Fleck, Leonard M.
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Mariotte'scher Fleck bei markhaltigen Nervenfasern der Retina
MARIOTTE'SCHER FLECK BEI MARKHALTIGEN NERVENFASERN DER RETINA Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Mariotte'scher Fleck bei markhaltigen ...
Dönitz, W.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Most people can stay fit and healthy into old age
Bulletin of the World Health Organization, 2014 Bruno Vellas tells Fiona Fleck why governments must act now to help older people stay fit and healthy.
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
OS CONFLITOS DE GERAÇÃO NO SISTEMA DE ENSINO SUPERIOR SOB PRISMA DA EPISTEMOLOGIA DE COLETIVOS DE PENSAMENTO [PDF]
, 2014 O objetivo deste ensaio teórico é analisar a aprendizagem escolar por meio dos conflitos de geração existentes sob o prisma da epistemologia de coletivos de pensamento de Ludwic Fleck, de modo a elucidar como a evolução nas gerações X, Y e Z influenciam ...
Soares, Antonio Augusto dos Santos +4 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source