Results 81 to 90 of about 10,263 (261)
Tough challenges for testing Ebola therapeutics
Bulletin of the World Health Organization, 2015 Therapies for Ebola virus disease are urgently needed, but they must be rigorously tested for safety and efficacy before any mass roll-out to patients. Fiona Fleck reports.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Revista Brasileira de Pesquisa em Educação em Ciências, 2011 Neste artigo sinalizamos possibilidades para a promoção do desenvolvimento profissional dos formadores de professores de Química, de modo que sua ação docente possa favorecer uma formação inicial de professores em consonância com as discussões ...
Fábio Peres Gonçalves +2 more
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Bulletin of the World Health Organization, 2015 Cheikh Niang tells Fiona Fleck why listening to people and helping them adapt their customs are essential in the fight against Ebola in western Africa.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Thailand?s health ambitions pay off
Bulletin of the World Health Organization, 2014 With political will and public health vision, Thailand is making essential health services available to all its citizens free of charge. Suwit Wibulpolprasert talks to Fiona Fleck.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Eliane Cristina Deckmann Fleck, Libro de Cirugía (São Leopoldo: Oikos, 2022), 658 pp.
Temas de Historia Argentina y AmericanaLos estudios sobre la actuación de la Compañía de Jesús en el continente americano han experimentado modificaciones en las últimas décadas con el descubrimiento y exploración de nuevas fuentes y su accesibilidad en formato digital.
Jefferson Aldemir Nunes
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Rapid Ebola tests hold promise
Bulletin of the World Health Organization, 2015 New rapid diagnostic tests for Ebola may help Guinea, Liberia and Sierra Leone reach zero cases and allow routine health services to resume. Fiona Fleck reports.
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