Results 31 to 40 of about 10,255 (211)
Automated pharmacovigilance system
Качественная клиническая практика, 2018 This article is about efficiency of online systems for pharmacovigilance (PV) processes management based on case study of implementation of PV system by Flex Databases.
O. A. Loginovskaya +2 more
doaj
Exploring the Introduction of Plug-In Hybrid Flex-Fuel Vehicles in Ecuador
Energies, 2019 In Europe, diesel combustion is being banned due to the NOx and PM2.5 emissions impact on air quality. The bus sector is being electrified and is increasing its use of alternative fuels, such as natural gas (in spark ignition engines) and bioethanol (in ...
Danilo Arcentales, Carla Silva
doaj +1 more source
Health Technology Assessment, 2020 Background: Patients with low estimated glomerular filtration rates may be at higher risk of post-contrast acute kidney injury following contrast-enhanced computed tomography imaging.
Mark Corbett +9 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Methods of working with pharmacovigilance signals
Качественная клиническая практика, 2018 This article is about the efficiency of web based systems for pharmacovigilance (PV) processes management in connection with pharmacovigilance signals based on case study of the implementation of Flex Databases PV system.
O. A. Loginovskaya +7 more
doaj
Allergenius, an expert system for the interpretation of allergen microarray results
World Allergy Organization Journal, 2014 Background An in vitro procedure based on a microarray containing many different allergen components has recently been introduced for use in allergy diagnosis. Recombinant and highly purified allergens belonging to different allergenic sources (inhalants,
Giovanni Melioli +9 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Network Pharmacology Based in Silico and in Vitro Anticancer Effects of Artemisia Maritima Extract in Human Prostate Cancer Cells [PDF]
Iranian Journal of Chemistry & Chemical EngineeringArtemisia maritima is an important medicinal plant with various bioactive molecules. Our study investigates the therapeutic potential of A. maritima extract against prostate cancer using a combination of network pharmacology, molecular docking, molecular
Pei Chen, Zhenxing Dai, Sihai Ye
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source