Results 101 to 110 of about 5,555,251 (415)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Flexibility capital and flexibility justice in smart energy systems

open access: yesEnergy Research & Social Science, 2019
Flexibility has increasing value across sectors of the economy, including energy. The ability to be flexible is affected by a wide variety of sociotechnical factors and determines what we term ‘flexibility capital’.
G. Powells, Michael J. Fell
semanticscholar   +1 more source

Waiver of Rights [PDF]

open access: yes, 2007
Part one of this memorandum provides a summary of questions asked and comments submitted in response to the DOL request for information ( RFI ) about waiver of FMLA rights.
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Controlling district heating and cooling networks to unlock flexibility: A review

open access: yes, 2018
Flexibility in district heating and cooling systems (thermal networks in general) is an important means to cope with the intermittent generation of heat and electricity as the share of renewable energy sources (RES) increases.
A. Vandermeulen, B. Heijde, L. Helsen
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Seattle, Washington [PDF]

open access: yes, 2011
Highlights from Seattle ...
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

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