Results 91 to 100 of about 4,355,972 (307)

Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics

Advanced Science
Semiconducting open‐shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class of semiconducting perylene diimide (PDI),
Jie Zhang, Haifen Luo, Wen Ma, Jingqi Lv, Bo Wang, Fengwei Sun, Weijie Chi, Zhuting Fang, Zhen Yang   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Radical-enhanced photo-activated ultralong organic phosphorescence

Nature Communications
Stimuli-responsive ultralong room temperature phosphorescence materials have attracted great attention due to their great potential in a wide variety of advanced applications.
Yuefei Wang, Zaiyong Zhang, Huanyu Yang, Shunjie Li, Xiaokang Yao, Huili Ma, Shengchen Yang, Suzhi Cai, Zhongfu An, Wei Huang   +9 more
doaj   +1 more source

Flexible and robust networks

, 2012
We consider networks with two types of nodes. The v-nodes, called centers, are hyper- connected and interact one to another via many u-nodes, called satellites.
Radulescu, O., Vakulenko, S. A.
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Secondary Order RC Sensor Neuron Circuit for Direct Input Encoding in Spiking Neural Network

Advanced Electronic Materials
In spiking neural networks (SNNs), artificial sensor neurons are crucial for converting real‐world analog information into encoded spikes. However, existing SNNs face challenges due to the inefficient implementation of input sensor neurons.
Simiao Yang, Deli Li, Jiuchao Feng, Binchen Gong, Qing Song, Yue Wang, Zhen Yang, Yonghua Chen, Qi Chen, Wei Huang   +9 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation

Journal of Nanobiotechnology
Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death and subsequent antitumor immune responses. However, dysregulated copper metabolism in tumor cells maintains homeostatic copper balance, while hypoxic ...
Lina Gu, Ying Sun, Tingjie Bai, Sijie Shao, Shumin Tang, Panpan Xue, Wanlin Cai, Xian Qin, Xuemei Zeng, Shuangqian Yan   +9 more
doaj   +1 more source

Recent Advances in Carborane-Based Crystalline Porous Materials

Molecules
The field of carborane research has witnessed continuous development, leading to the construction and development of a diverse range of crystalline porous materials for various applications. Moreover, innovative synthetic approaches are expanding in this
Yuxuan Meng, Xi Lin, Jinyi Huang, Liangliang Zhang   +3 more
doaj   +1 more source