Results 61 to 70 of about 196,547 (296)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Flexible Symbiosis for Simulation Optimization in Production Scheduling: A Design Strategy for Adaptive Decision Support in Industry 5.0

Journal of Manufacturing and Materials Processing
In the rapidly evolving landscape of Industry 4.0 and the transition towards Industry 5.0, manufacturing systems face the challenge of adapting to dynamic, hyper-customized demands.
Mohaiad Elbasheer, Francesco Longo, Giovanni Mirabelli, Vittorio Solina   +3 more
doaj   +1 more source

Rewarding the Factory Workers: How to Select the Right Measures for an Effective Pay-for-Performance System [PDF]

, 2017
Aims: A Performance related pay (PRP) plan rewards employees with a financial payment, either consolidated or non consolidated, following an assessment of their performance and, typically, the achievement of objectives.
Biazzo S., de Crescenzo A. M., Panizzolo R.   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A New Lower Bound for Flexible Flow Shop Problem with Unrelated Parallel Machines

International Journal of Industrial Engineering and Production Research, 2014
Flexible flow shop scheduling problem (FFS) with unrelated parallel machines contains sequencing in flow shop where, at any stage, there exists one or more processors. The objective consists of minimizing the maximum completion time.
Nasim Nahavandi, Ebrahim Asadi Gangraj
doaj  

Efficiency of the solution representations for the hybrid flow shop scheduling problem with makespan objective [PDF]

, 2019
In this paper we address the classical hybrid flow shop scheduling problem with makespan objective. As this problem is known to be NP-hard and a very common layout in real-life manufacturing scenarios, many studies have been proposed in the literature to
Fernández-Viagas Escudero, Víctor, Framiñán Torres, José Manuel, Pérez González, Paz   +2 more
core  

Transforming failure into success through organisational learning: An analysis of a manufacturing information system [PDF]

, 2001
This paper describes the idiosyncracies of a case study company, through highlighting issues and problems experienced during their attempts to evaluate, implement and realise the holistic implications of a manufacturing information system. Although the
Irani, Z, Love, PED, Sharif, A M
core   +1 more source

Scheduling A Flexible Flow Shops Problem Using Dea

, 2012
This paper considers a scheduling problem in flexible flow shops environment with the aim of minimizing two important criteria including makespan and cumulative tardiness of jobs. Since the proposed problem is known as an Np-hard problem in literature, we have to develop a meta-heuristic to solve it. We considered general structure of Genetic Algorithm
Dadkhah, Fatemeh, Akbarpour, Hossein Ali
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source